Results 111 to 120 of about 2,007,077 (278)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Transition Planning -- Responsibilities and Strategies [PDF]
, 2011 This meta-synthesis of the literature, on transition planning for youth with disabilities, examines several important facets that impact the post school outcomes for students with disabilities.
Arnold, Art
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Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
SukisokThis case study aims to explore the lived experiences of low- to middle-income young Filipino families in their management and balancing of family livelihood, specifically managing household finance and child-rearing responsibilities as they transition ...
Kenna Abarientos +5 more
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RESPONSIBILITIES IN MANAGEMENT OF TOURIST DESTINATIONS [PDF]
Over the past six decades, tourism has experienced continued growth and diversification to become one of the largest and fastest growing economic sectors in the world.
Catalina SITNIKOV, Mirela MAZILU
core
Roles and Responsibilities of Nonprofit Boards: the Peace Case [PDF]
, 2012 This exploratory study identifies the levels of importance and fulfillment of board roles and responsibilities by nonprofit peacemaking organization board members and executive directors.
Kennelly, Patrick
core +2 more sources
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
The development of responsibility in product designers [PDF]
, 2009 Investigations of ethics in product design have been limited. This paper offers an insight into designer's perceptions of responsibilities over three levels of expertise; first year design students, graduating design students, and design practitioners ...
Birkett, Stacey +2 more
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