Results 101 to 110 of about 5,256,565 (278)
The Responsibility Quantification (ResQu) Model of Human Interaction with Automation
, 2020 Intelligent systems and advanced automation are involved in information collection and evaluation, in decision-making and in the implementation of chosen actions. In such systems, human responsibility becomes equivocal.
Douer, Nir, Meyer, Joachim
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Responsibility modulates neural mechanisms of outcome processing : an ERP study
, 2011 The role of personal responsibility in decision-making and its influence on the outcome evaluation process have been investigated relatively rarely in cognitive neuroscience.
Han, Chunhui +4 more
core +1 more source
Moral Responsibility, Justice, and Freedom [PDF]
, 2020 Freedom, and in particular, the freedom of human beings, is a hot topic within the field of metaphysics. In this paper, instead of arguing for the truth of a particular position on freedom, I explore whether a particular position, compatibilism, might be
Smith, Jonathan
core +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Desert, Control, and Moral Responsibility [PDF]
, 2019 In this paper, I take it for granted both that there are two types of blameworthiness—accountability blameworthiness and attributability blameworthiness—and that avoidability is necessary only for the former. My task, then, is to explain why avoidability
Portmore, Douglas W.
core
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Resources, 2017 Regional planning approaches to mining infrastructure aim to reduce the conflict associated with mining operations and existing land uses, such as urban areas and biodiversity conservation, as well as the cumulative impacts that occur offsite.
Alex M. Lechner +8 more
doaj +1 more source