Results 91 to 100 of about 2,478,118 (289)
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Navigating toward acceptance of death: Home-dwelling patients in the palliative phase
Background As global life expectancy increases, the need for palliative care grows. Recognizing the deeply personal and diverse nature of individuals’ end-of-life experiences, palliative care for home-dwelling patients requires a flexible and person ...
Katrine Staats +2 more
doaj +1 more source
The Farm Fresh Healthcare Project: Analysis of a Hybrid Values-based Supply Chain
An emerging literature on values-based supply chains offers models for meeting both the scale-based requirements and values-based goals of farm-to-institution initiatives.
Kendra Klein, Ariane Michas
doaj +1 more source
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Shifting the Blame: On Delegation and Responsibility [PDF]
To fully understand the motives for delegating a decision right, it is important to study responsibility attributions for outcomes of delegated decisions.
Björn Bartling, Urs Fischbacher
core
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Corporate Responsibility Practices in Bangladesh: Results from a Benchmark Study [PDF]
This paper aims to provide useful insights in understanding the overall corporate responsibility status in the corporate world of Bangladesh as well as to obtain perception of the relationship of corporations with civil society, workers and the consumers.
Centre for Policy Dialogue (CPD)
core
Prospecting the protein design landscape
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
STRATEGIES OF CORPORATE SOCIAL RESPONSIBILITY IN THE EUROPEAN UNION [PDF]
The present paper emphasizes the corporate social responsibility (CSR) state and development strategies in the European Union and at the level of the Romanian business environment.
Joldes Cosmin, Iamandi Irina Eugenia
core
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source

