Results 91 to 100 of about 1,451,435 (348)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
How to Manage Disasters while Considering Responsibility to Protect Theory? [PDF]
Bull Emerg Trauma, 2021 Esfandiar H +3 more
europepmc +1 more source
Genocide, Obligations Erga Omnes and Responsibility to Protect [PDF]
, 2017 In 2007, the International Court of Justice declared that states have a duty to prevent genocide from occurring in another state since the prevention and punishment of genocide is a concern of every state and of the international community as a whole ...
Longobardo, M., Longobardo, M.
core
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling
FEBS Open Bio, EarlyView.Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang +7 more
wiley +1 more source
The European Parliament and the conflict in Libya (2011): an efficient moral platform?
Revista CIDOB d'Afers Internacionals, 2013 The actions of the European Parliament with respect to the internal crisis in Libya and the international interventions carried out in the country in 2011 contradict the widely-held perception of the European Union’s passivity concerning the events of ...
Stelios Stavridis +1 more
doaj
If Walls Could Talk: How Landlords Fail to Obey Childhood Lead Poisoning Prevention Laws in Bushwick [PDF]
, 2009 Bushwick is a low-income community of color located in the heart of NYC's so called "lead belt": DHMH data has often ranked Bushwick as one of the communities with the largest numbers of children with reported elevated blood lead levels.
core
FEBS Open Bio, EarlyView.KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli +9 more
wiley +1 more source
This State of Independence Shall Be: Africa, the West, and the Responsibility to Protect
Relaciones Internacionales, 2014 It is argued today that African states largely endorsed the principle of the responsibility to protect and the establishment of the international criminal court (ICC) only to reverse course in equally great majorities at the moment of implementation ...
Siba N'Zatioula GROVOGUI
doaj
FEBS Open Bio, EarlyView.We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies +3 more
wiley +1 more source