Results 101 to 110 of about 86,547,439 (243)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Genocide, Obligations Erga Omnes and Responsibility to Protect [PDF]
, 2017 In 2007, the International Court of Justice declared that states have a duty to prevent genocide from occurring in another state since the prevention and punishment of genocide is a concern of every state and of the international community as a whole ...
Longobardo, M.
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Responsibility to Protect: lessons from South Kivu [PDF]
Forced Migration Review, 2007 Protection is one of the components of the new UN -led cluster approach in emergency environments.1 Can the protection cluster mobilise the international community to protect civilians in areas where states are either unwilling or unable to do so?
Jaya Murthy
doaj
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
The international community's responsibility to protect
, 2010 Griffith Business School, Department of International Business and Asian StudiesNo Full ...
Glanville, Luke, Luke Glanville
core +1 more source
Addressing the Boko Haram-Induced Mental Health Burden in Nigeria [PDF]
Health and Human Rights, 2020 Adewale Olusola Adeboye
doaj
Responsibility to Protect and the Challenges of Displaced Men in Nigeria
Journal of Danubian Studies and Research, 2020 This study addresses responsibility to protect and the challenges of displaced men in Nigeria. It argues that the challenges facing displaced people in Nigeria as a result of Boko Haram, natural and man-made disasters, as well as the Hausa-Fulani ...
Ejiroghene Augustine Oghuvbu +1 more
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