Results 91 to 100 of about 86,547,439 (243)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
The European Parliament and the conflict in Libya (2011): an efficient moral platform?
Revista CIDOB d'Afers Internacionals, 2013 The actions of the European Parliament with respect to the internal crisis in Libya and the international interventions carried out in the country in 2011 contradict the widely-held perception of the European Union’s passivity concerning the events of ...
Stelios Stavridis +1 more
doaj
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
The responsibility to protect: towards human security?
, 2007 The paper explores the potential of the responsibility to protect to alleviate human insecurity arising from mass human rights ...
McClean, E.
core
The responsibility to protect: the role of international human rights law
, 2007 This paper explores the potential of the responsibility to protect, having gained the support of the member states of the United Nations (UN) at the 2005 World Summit, as a framework for the UN to address genocide, war crimes, ethnic cleansing and crimes
McClean, E.
core +1 more source
This State of Independence Shall Be: Africa, the West, and the Responsibility to Protect
Relaciones Internacionales, 2014 It is argued today that African states largely endorsed the principle of the responsibility to protect and the establishment of the international criminal court (ICC) only to reverse course in equally great majorities at the moment of implementation ...
Siba N'Zatioula GROVOGUI
doaj
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source