Results 41 to 50 of about 200,089 (297)
mit-ll-responsible-ai/hydra-zen: Release v0.7.0rc1
, 2022 Configurable, reproducible, and scalable workflows in Python, via ...
Ryan Soklaski +2 more
core +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Not All That Can Be Automated Should Be Automated – Strategic Minimalism as a Disciplined and Ethically Grounded Approach to AI Adoption [PDF]
Business Ethics and LeadershipAs organizations accelerate the adoption and use of artificial intelligence, a common misconception arises that equates automation with progress and strategic necessity. This paper argues that not all that can be automated should be automated.
Victor Frimpong
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
How can we manage biases in artificial intelligence systems – A systematic literature review
International Journal of Information Management Data Insights, 2023 Artificial intelligence is similar to human intelligence, and robots in organisations always perform human tasks. However, AI encounters a variety of biases during its operational process in the online economy.
Dr. Varsha P．S．
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
A Systematic Review of Responsible Artificial Intelligence Principles and Practice
Applied System InnovationThe accelerated development of Artificial Intelligence (AI) capabilities and systems is driving a paradigm shift in productivity, innovation and growth. Despite this generational opportunity, AI is fraught with significant challenges and risks.
Lakshitha Gunasekara +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Where Assessment Validation and Responsible AI Meet [PDF]
The core principles of validity, reliability, and fairness have been the foundation of ethical assessment practices, as discussed in classical validation theories (e.g., Chapelle et al., 2008; Kane, 1992, 2013) and the American Educational Research ...
Jill Burstein,Geoffrey T. LaFlair
core +1 more source