Responsive Neurostimulation of the Thalamus for the Treatment of Refractory Epilepsy [PDF]
Frontiers in Human Neuroscience, 2022 IntroductionOne-third of patients with epilepsy continue to have seizures despite antiepileptic medications. Some of these refractory patients may not be candidates for surgical resection primarily because the seizure onset zones (SOZs) involve both ...
Jorge A. Roa +9 more
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Unearthing the mechanisms of responsive neurostimulation for epilepsy [PDF]
Communications Medicine, 2023 Responsive neurostimulation (RNS) is an effective therapy for people with drug-resistant focal epilepsy. In clinical trials, RNS therapy results in a meaningful reduction in median seizure frequency, but the response is highly variable across individuals,
Vikram R. Rao, John D. Rolston
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Responsive neurostimulation (RNS) programming [PDF]
NeurotherapeuticsProgramming of RNS is an iterative process involving a logical progression of patient-specific electrocorticographic biomarker detections that inform stepwise progression of stimulation parameters.
Philip M. McCarthy, David E. Burdette
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Responsive neurostimulation for treatment of pediatric drug-resistant epilepsy
Epilepsy and Behavior Case Reports, 2018 Responsive neurostimulation for epilepsy involves an implanted device that delivers direct electrical brain stimulation in response to detection of incipient seizures.
Nilika S. Singhal +6 more
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Frontiers in Human Neuroscience, 2022 IntroductionResponsive neurostimulation is an evolving therapeutic option for patients with treatment-refractory epilepsy. Open-loop, continuous stimulation of the anterior thalamic nuclei is the only approved modality, yet chronic stimulation rarely ...
Chaim M. Feigen, Emad N. Eskandar
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Brain Stimulation, 2021 Background: An implanted device for brain-responsive neurostimulation (RNS® System) is approved as an effective treatment to reduce seizures in adults with medically-refractory focal epilepsy.
Sharon Chiang +5 more
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Centromedian nucleus targeting in the pediatric population treated with thalamic responsive neurostimulation for drug‐resistant epilepsy [PDF]
Epilepsia OpenThe management of drug‐resistant epilepsy (DRE) in the pediatric population using neurostimulation of the centromedian (CM) nucleus of the thalamus (CMN) has been reported to be effective and safe.
Marian Michael Bercu +8 more
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Clinical outcomes following responsive neurostimulation implantation: a single center experience [PDF]
Frontiers in Neurology, 2023 BackgroundResponsive neurostimulation (RNS) is an implantable device for persons with medically refractory focal-onset epilepsy. We report a single-center experience for RNS outcomes with special focus on stereoelectroencephalography (sEEG) for seizure ...
Micaela R. Owens +2 more
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The Utility of Responsive Neurostimulation for the Treatment of Pediatric Drug-Resistant Epilepsy [PDF]
Brain Sciences, 2023 Drug-resistant epilepsy (DRE) has a strongly negative impact on quality of life, as well as the development of pediatric patients. Surgical treatments have evolved over time, including more invasive craniotomies for resection or disconnection.
Martin G. Piazza +3 more
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Responsive neurostimulation in children, adolescents, and young Adults—Longitudinal effectiveness and safety [PDF]
NeurotherapeuticsDrug-resistant epilepsy (DRE) remains challenging to treat, and seizure control often fluctuates over time. Responsive neurostimulation (RNS) is increasingly used in pediatric and young adult populations, yet long-term effectiveness and safety data are ...
Steven T. Lee +10 more
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