Results 51 to 60 of about 3,216 (177)
Advanced Science, EarlyView.A multiscale computational framework links single‐nanoparticle magnetoelectric behavior to tissue‐level electric field distributions, integrating experimental data from nanoparticle characterization and in vitro stimulation setups. Applied to a cortical slice configuration, the framework predicts optimal MENP concentrations and stimulation parameters ...
Marta Bonato +10 more
wiley +1 more source
Targeted Mechanogenetics to Modulate Specific Deep Neural Circuits
Advanced Science, EarlyView.This study introduces mechanogenetics, a nanobubble‐enhanced sonogenetic strategy for selective modulation of feeding‐related neural circuits in the mouse lateral hypothalamus. Mechanogenetic stimulation modulates feeding behavior through glutamatergic projections from the lateral hypothalamus to the ventral tegmental area, highlighting its potential ...
Xuandi Hou +3 more
wiley +1 more source
Epilepsia Open, 2021 Objectives The gold standard for the management of drug‐resistant focal epilepsy (DRE) is resection of epileptogenic zone. However, some patients may not be candidates for resection.
Ifrah Zawar +5 more
doaj +1 more source
Emerging Trends in Neuromodulation for Treatment of Drug-Resistant Epilepsy
Frontiers in Pain Research, 2022 Epilepsy is a neurological disorder that affects more than 70 million people globally. A considerable proportion of epilepsy is resistant to anti-epileptic drugs (AED).
Mohamed Abouelleil +2 more
doaj +1 more source
Responsive neurostimulation for the treatment of medically intractable epilepsy
Brain Research Bulletin, 2013 With an annual incidence of 50/100,000 people, nearly 1% of the population suffers from epilepsy. Treatment with antiepileptic medication fails to achieve seizure remission in 20-30% of patients. One treatment option for refractory epilepsy patients who would not otherwise be surgical candidates is electrical stimulation of the brain, which is a ...
Chong, Liu +7 more
openaire +2 more sources
Interventional therapies for chronic heart failure: An overview of recent developments
ESC Heart Failure, Volume 12, Issue 2, Page 1081-1094, April 2025.Abstract Heart failure (HF), the final manifestation of most cardiovascular diseases, has become a major global health concern, affecting millions of individuals. Despite basic drug treatments, patients present with high morbidity and mortality rates. However, recent advancements in interventional therapy have shown promising results in improving the ...
Bingchen Guo +7 more
wiley +1 more source
Epilepsy and Behavior Case Reports, 2018 Objectives: To match responsive neurostimulator (RNS) and polysomnographic data to determine if RNS detections and stimulations correlate with measurements of sleep disordered breathing and continuous glucose measurements (CGM). Materials and methods: In
Katie M. Kinnear +3 more
doaj +1 more source
Responsive neurostimulation in pediatric patients with drug-resistant epilepsy
Neurosurgical Focus, 2022 OBJECTIVE Medically refractory epilepsy remains a therapeutic challenge when resective surgery is not a practical option and indirect neurostimulation efficacy may be limited. In these instances responsive neurostimulation (RNS) has been used in adults, with good outcomes in most patients.
Nicole, Falls +2 more
openaire +2 more sources
Clinical trial barriers in neurostimulation for pediatric drug‐resistant epilepsy
Epileptic Disorders, EarlyView.Abstract Objective The NeuroPace responsive neurostimulation (RNS) System effectively treats focal drug‐resistant epilepsy (DRE) in adults but lacks pediatric regulatory approval. Despite effective off‐label pediatric use, systemic device‐trial challenges have impeded label expansion.
Mira C. Hasner +15 more
wiley +1 more source
Evidence for long memory in focal seizure duration
Epilepsia Open, 2021 Objective A major source of disability for people with epilepsy involves uncertainty surrounding seizure timing and severity. Although patients often report that long seizure‐free intervals are followed by more severe seizures, there is little ...
Joline M. Fan +2 more
doaj +1 more source