Results 81 to 90 of about 17,837,860 (297)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Resting-state fMRI studies in epilepsy [PDF]

Neuroscience Bulletin, 2012
Epilepsy is a disease characterized by abnormal spontaneous activity in the brain. Resting-state functional magnetic resonance imaging (RS-fMRI) is a powerful technique for exploring this activity. With good spatial and temporal resolution, RS-fMRI is a promising approach for accurate localization of the focus of seizure activity. Although simultaneous
, Wurina, Yu-Feng, Zang, Shi-Gang, Zhao
openaire   +2 more sources

Resting-state functional connectivity of orthographic networks in acquired dysgraphia

Frontiers in Psychology, 2015
Introduction. While task-based fMRI has been used extensively to study the functional neural networks that instantiate cognitive functions, there is increasing interest in analyzing the activity of the brain while it is not performing a task – in the ...
Gali Ellenblum
doaj   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Resting-state functional connectivity alterations after mild COVID-19 infection

BMC Infectious Diseases
The long-term effects of coronavirus disease 2019 (COVID-19) are more pronounced after severe infection, although years after the pandemic was declared, long-term neurological complications after mild infection have begun to unfold.
Anna Szente, Ákos Arató, Husamalddin Ali Alhour, Gábor Perlaki, Gergely Orsi, Szilvia Anett Nagy, Eszter Áfra, Barnabás Dudás, Dalma Tényi, Péter Barsi, Norbert Kovács, József Janszky, Gergely Darnai   +12 more
doaj   +1 more source

Resting state networks and consciousness.Alterations of multiple resting state network connectivity in physiological, pharmacological and pathological consciousness states.

Frontiers in Psychology, 2012
In order to better understand the functional contribution of resting state activity to conscious cognition, we aimed to review increases and decreases in fMRI functional connectivity under physiological (sleep), pharmacological (anesthesia) and ...
Lizette eHeine, Andrea eSoddu, Francisco eGomez, Audrey eVanhaudenhuyse, Luaba eTshibanda, Marie eThonnard, Vanessa eCharland-Verville, Murielle eKirsch, Steven eLaureys, Steven eLaureys, Athena eDemertzi   +10 more
doaj   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

On nodes and modes in resting state fMRI

NeuroImage, 2014
ISSN:1095 ...
Karl J. Friston, Joshua Kahan, Adeel Razi, Klaas Enno Stephan, Olaf Sporns   +4 more
openaire   +6 more sources

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source