Results 71 to 80 of about 12,674,101 (309)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Automatic selection of resting-state networks with functional magnetic resonance imaging
Frontiers in Neuroscience, 2013 Functional magnetic resonance imaging (fMRI) during a resting-state condition can reveal the co-activation of specific brain regions in distributed networks, called resting-state networks, which are selected by independent component analysis (ICA) of the
Silvia Francesca eStorti +8 more
doaj +1 more source
Stress Impact on Resting State Brain Networks. [PDF]
PLoS ONE, 2013 Resting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal
José Miguel Soares +8 more
doaj +1 more source
Altered resting state complexity in schizophrenia [PDF]
NeuroImage, 2012 The complexity of the human brain's activity and connectivity varies over temporal scales and is altered in disease states such as schizophrenia. Using a multi-level analysis of spontaneous low-frequency fMRI data stretching from the activity of individual brain regions to the coordinated connectivity pattern of the whole brain, we investigate the role
Danielle S. Bassett +4 more
openaire +2 more sources
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Spatiotemporal nonlinearity in resting-state fMRI of the human brain
, 2008 In this work, the spatiotemporal nonlinearity in resting-state fMRI data of the human brain was detected by nonlinear dynamics methods. Nine human subjects during resting state were imaged using single-shot gradient echo planar imaging on a 1.5T scanner.
Weng XC(翁旭初) +2 more
core +1 more source
Pattern classification of large-scale functional brain networks : identification of informative neuroimaging markers for epilepsy [PDF]
, 2012 The accurate prediction of general neuropsychiatric disorders, on an individual basis, using resting-state functional magnetic resonance imaging (fMRI) is a challenging task of great clinical significance.
GuangMing Lu +20 more
core +1 more source
Resting state functional connectivity underlying musical creativity
NeuroImage, 2020 While the behavior of “being musically creative”— improvising, composing, songwriting, etc.—is undoubtedly a complex and highly variable one, recent neuroscientific investigation has offered significant insight into the neural underpinnings of many of ...
David M. Bashwiner +5 more
doaj +1 more source
On nodes and modes in resting state fMRI
NeuroImage, 2014 ISSN:1095 ...
Karl J. Friston +4 more
openaire +5 more sources