Results 101 to 110 of about 11,023,971 (404)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Spontaneous Associations under Mild Compression of the Hippocampal Area
Вестник Московского университета. Серия 14: ПсихологияBackground. The network principle of cognitive phenomena implementation in the brain presupposes self-organization of distributed neuronal elements into a network for processing information demanded by the organism at a given moment.
Olga A. Krotkova +3 more
doaj +1 more source
Pattern classification of large-scale functional brain networks : identification of informative neuroimaging markers for epilepsy [PDF]
, 2012 The accurate prediction of general neuropsychiatric disorders, on an individual basis, using resting-state functional magnetic resonance imaging (fMRI) is a challenging task of great clinical significance.
GuangMing Lu +20 more
core +1 more source
The Role of Resting-State Network Functional Connectivity in Cognitive Aging
Frontiers in Aging Neuroscience, 2020 Aging is associated with disruptions in the resting-state functional architecture of the brain. Previous studies have primarily focused on age-related declines in the default mode network (DMN) and its implications in Alzheimer’s disease. However, due to
Hanna K. Hausman +15 more
semanticscholar +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
Quantifying the Variability in Resting-State Networks [PDF]
Entropy, 2019 Recent precision functional mapping of individual human brains has shown that individual brain organization is qualitatively different from group average estimates and that individuals exhibit distinct brain network topologies. How this variability affects the connectivity within individual resting-state networks remains an open question.
Isaura Oliver +3 more
openaire +3 more sources
Automatic selection of resting-state networks with functional magnetic resonance imaging
Frontiers in Neuroscience, 2013 Functional magnetic resonance imaging (fMRI) during a resting-state condition can reveal the co-activation of specific brain regions in distributed networks, called resting-state networks, which are selected by independent component analysis (ICA) of the
Silvia Francesca eStorti +8 more
doaj +1 more source
Spatiotemporal nonlinearity in resting-state fMRI of the human brain
, 2008 In this work, the spatiotemporal nonlinearity in resting-state fMRI data of the human brain was detected by nonlinear dynamics methods. Nine human subjects during resting state were imaged using single-shot gradient echo planar imaging on a 1.5T scanner.
Weng XC(翁旭初) +2 more
core +1 more source
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source