Results 61 to 70 of about 101,028 (286)
Dynamic Reconfiguration of Functional Topology in Human Brain Networks: From Resting to Task States
Neural Plasticity, 2020 Task demands evoke an intrinsic functional network and flexibly engage multiple distributed networks. However, it is unclear how functional topologies dynamically reconfigure during task performance. Here, we selected the resting- and task-state (emotion
Wenhai Zhang +3 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Stomach-brain synchrony reveals a novel, delayed-connectivity resting-state network in humans
eLife, 2018 Resting-state networks offer a unique window into the brain’s functional architecture, but their characterization remains limited to instantaneous connectivity thus far.
Ignacio Rebollo +3 more
doaj +1 more source
Resting-state networks in the macaque at 7T
NeuroImage, 2011 Assessment of brain connectivity has revealed that the structure and dynamics of large-scale network organization are altered in multiple disease states suggesting their use as diagnostic or prognostic indicators. Further investigation into the underlying mechanisms, organization, and alteration of large-scale brain networks requires a homologous ...
R. Matthew Hutchison +5 more
openaire +5 more sources
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
THE RELATIONSHIP BETWEEN THE DEFAULT MODE RESTING STATE NEURAL NETWORK, RESPIRATORY SINUS ARRHYTHMIA, AND SELF-FOCUSED COGNITION: AN EMPIRICAL ANALYSIS [PDF]
, 2013 Functional activity within the default mode resting state neural network (RSNN) and the resting respiratory sinus arrhythmia (RSA) may represent an integrated neural and peripheral cardiovascular index of the baseline, resting state in humans.
Egizio, Victoria
core
Resting state network estimation in individual subjects [PDF]
NeuroImage, 2013 Resting state functional magnetic resonance imaging (fMRI) has been used to study brain networks associated with both normal and pathological cognitive functions. The objective of this work is to reliably compute resting state network (RSN) topography in single participants.
Carl D. Hacker +6 more
openaire +3 more sources
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Multiscale network activity in resting state fMRI [PDF]
2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2016 The brain is inherently multiscalar in both space and time. We argue that this multiscalar nature is reflected in the blood oxygenation level dependent (BOLD) fluctuations used to map functional connectivity. We present evidence that global fluctuations in activity, quasiperiodic spatiotemporal patterns, and aperiodic time-varying activity coexist ...
Shella D. Keilholz +7 more
openaire +2 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source