Results 91 to 100 of about 235,919 (281)

Pre–emption right of shareholders to purchase shares for sale in private limited liability companies: the problematic legal remedies

open access: yesBusiness: Theory and Practice, 2016
This article analyses the problems that can arise when implementing the rights of shareholders in private limited liability companies to purchase the shares of another shareholder being for sale in priority to others and the possible legal remedies for ...
Virginijus Bitė   +1 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

Social restitution: tools and actions to rehumanise and transform injustice

open access: yesActa Academica
Restitution has predominantly been described as a legal rather than a social action in international law, as well as in South Africa’s history of truth, reconciliation and redress policies after the end of apartheid.
Sharlene Swartz
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Dynamics of a single particle in a horizontally shaken box

open access: yes, 1997
We study the dynamics of a particle in a horizontally and periodically shaken box as a function of the box parameters and the coefficient of restitution.
Drossel, Barbara, Prellberg, Thomas
core   +2 more sources

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

Rheological properties for inelastic Maxwell mixtures under shear flow

open access: yes, 2009
The Boltzmann equation for inelastic Maxwell models is considered to determine the rheological properties in a granular binary mixture in the simple shear flow state. The transport coefficients (shear viscosity and viscometric functions) are {\em exactly}
Garzo, Vicente, Trizac, Emmanuel
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Legal effects of the avoidance of the contract for the international sale of goods [PDF]

open access: yesStrani pravni život
The subject of this paper are the legal consequences of the termination of the contract for the international sale of goods under the regime of the UN Convention on Contracts for the International Sale of Goods.
Zdravković Uroš I.
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

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