Results 61 to 70 of about 226,037 (263)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Coefficient of Restitution as a Fluctuating Quantity

open access: yes, 2011
The coefficient of restitution of a spherical particle in contact with a flat plate is investigated as a function of the impact velocity. As an experimental observation we notice non-trivial (non-Gaussian) fluctuations of the measured values. For a fixed
A. Hatzes   +6 more
core   +1 more source

A discrete particle simulation study on the influence of restitution coefficient on spout fluidized bed dynamics [PDF]

open access: yes, 2008
In this paper the influence of the normal restitution coefficient on the bed dynamics\ud during different flow regimes was studied using the discrete element model.
Antonyuk, S.   +4 more
core   +3 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Restitution in the context of institutional lock-in

open access: yesJournal for Perspectives of Economic Political and Social Integration, 2014
This article presents the problem of lack of restitution in Poland in the political, social and economic context. The author presents the theory of institutional lock-in, referring to the hitherto course of the political, social and economic ...
Załęczna Magdalena
doaj   +1 more source

Tracer diffusion in granular shear flows

open access: yes, 2002
Tracer diffusion in a granular gas in simple shear flow is analyzed. The analysis is made from a perturbation solution of the Boltzmann kinetic equation through first order in the gradient of the mole fraction of tracer particles.
A. Santos   +35 more
core   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Municipality (State Treasury) in the class of persons entitled to restitution of expropriated real estate

open access: yesPrzegląd Prawniczy Uniwersytetu im. Adama Mickiewicza, 2014
The paper aims to describe a legal problem in the application of rules governing the restitution of expropriated real estate - namely a situation in which one of the entities entitled to restitution of expropriated property, turns out to be a ...
Jakub Terlega
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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