Results 61 to 70 of about 1,314,107 (247)

The Effect of Heat Therapy on the Severity of Restless Legs Syndrome and Sleep Quality in the Elderly

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2022
Objective Restless legs syndrome is a neurological condition associated with an irresistible urge to move the legs and eventually leads to discomfort, sleep disorders, and reduced quality of life.
Hojjat Azizkhani, Hossein Nazmieh, Arefeh Dehghani, Khadijeh Nasiriani   +3 more
doaj  

NKX2‐1 Downstream Regulatory Structural Variants Explain a Substantial Proportion of Molecular Diagnoses in Patients With Benign Hereditary Chorea

Movement Disorders, EarlyView.
Abstract Background NKX2‐1–related disorders (NKX2‐1‐RDs) classically present with a triad of neurological, endocrine, and pulmonary manifestations, including benign hereditary chorea. However, in a fraction of patients, NKX2‐1 coding variants are not detected, and variants outside the NKX2‐1 locus have been reported.
Robin Wijngaard, Lucy Dougherty‐de Miguel, German Demidov, Galuh Astuti, Amaia Lasa‐Aranzasti, Ana Cueto‐González, Marta Correa‐Vela, Carlos Lázaro‐Hernández, Charlotte A. Haaxma, Clara D.M. van Karnebeek, David Gómez‐Andrés, Ignacio Iglesias‐Serrano, Jiddeke M. van de Kamp, Jolanda Schieving, Laura Trujillano, Marc Engelen, Beatriz Muñoz‐Cabello, Roderick P.P.W.M. Maas, Thatjana Gardeitchik, Victoria Gonzalez, Annemarie de Vreugd, Cristina Pérez‐Sanchez, Elisabet Lloveras, Erik‐Jan Kamsteeg, Maartje Pennings, Natalia Rey‐Viñets, Javier Sánchez, Ronald van Beek, Antonio Moreno‐Galdó, Lisenka E.L.M. Vissers, Kornelia Neveling, Anna Marcé‐Grau, Machteld M. Oud, Belén Pérez‐Dueñas   +33 more
wiley   +1 more source

Childhood restless legs syndrome

, 2014
BACKGROUND: The last 20 years witnessed increased medical awareness regarding restless legs syndrome (Willis-Ekbom disease) among adults and children. However, it remains underdiagnosed and undertreated.
Pereira Jr.,Jose Carlos, Pradella-Hallinan,Márcia, Alves,Rosana Cardoso   +2 more
core   +1 more source

Developing the Dopamine D3 Receptor (D3R) Antagonist, (R)‐VK4‐116, as a Non‐Opioid Medication for the Treatment of Opioid Use Disorder

Medicinal Research Reviews, EarlyView.
ABSTRACT Opioid use disorder (OUD) remains a major global health challenge, and currently approved treatments (methadone, buprenorphine, and naltrexone) are all opioid receptor‐targeting drugs with limitations in access, adherence, stigma, and use in polysubstance use disorders. Because the dopamine D3 receptor (D3R) is enriched in limbic brain regions
Chia‐Kuei Wu, Yu‐Chih Lin, Junfeng Huang, Bangwei Ding, Pramod Terse, Rahul Nandre, Haksong Jin, Molly Congdon, Kun Shen, Philip Sanderson, Gregory Tawa, Stephanie Mounaud, Marta De Santis, Donald Lo, Elizabeth A. Ottinger, Amy Hauck Newman   +15 more
wiley   +1 more source

Use of Integrative Medicine Practices by Pregnant Women with Restless Legs Syndrome

Journal of Nursology
Objective: To determine the use of integrative medicine practices in pregnant women with restless legs syndrome. Methods: This cross-sectional descriptive study was conducted in the perinatology service and outpatient clinic of a university hospital ...
Fulya Çağli, Mürüvvet Başer, Özlem Kaplan   +2 more
doaj   +1 more source

Restless Legs Syndrome and Leg Motor Restlessness in Parkinson’s Disease [PDF]

Parkinson's Disease, 2015
Sleep disturbances are important nonmotor symptoms in Parkinson’s disease (PD) that are associated with a negative impact on quality of life. Restless legs syndrome (RLS), which is characterized by an urge to move the legs accompanied by abnormal leg sensations, can coexist with PD, although the pathophysiology of these disorders appears to be ...
Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Koichi Hirata   +3 more
openaire   +3 more sources

Neurotrophic Signaling, Sleep Physiology, and Retinal Neuroprotection: Integrative Mechanisms and Therapeutic Implications for Glaucoma

Sensory Neuroscience, EarlyView.
Glaucoma is increasingly understood as a neurodegenerative disorder shaped by sleep and circadian physiology, not intraocular pressure alone. Sleep loss and obstructive sleep apnea suppress BDNF–TrkB neurotrophic signaling, impair sleep‐dependent glymphatic clearance, and trigger microglial neuroinflammation and vascular insult at the optic nerve head,
Karyme M. Alemán‐Villa, Emiliano Terán, Javier A. Magaña‐Gómez, Loranda Calderón‐Zamora, Beatriz K. De la Herrán‐Arita, Alberto K. De la Herrán‐Arita   +5 more
wiley   +1 more source

Iron and The Restless Legs Syndrome [PDF]

Sleep, 1998
Using blinded procedures, determine the relation between serum ferritin levels and severity of subjective and objective symptoms of the restless legs syndrome (RLS) for a representative patient sample covering the entire adult age range.All patient records from the past 4 years were retrospectively reviewed to obtain data from all cases with RLS.
E R, Sun, C A, Chen, G, Ho, C J, Earley, R P, Allen   +4 more
openaire   +2 more sources

Dopamine agonists for restless legs syndrome 

Restless Legs Syndrome (RLS) is a common neurological disorder characterised by an uncontrollable urge to move the legs. Dopamine agonists are widely used as first or second-line treatments for RLS due to their efficiency in alleviating the symptoms of ...
Michael J Keogh, Pran Phakdeekitcharoen
core   +1 more source

Restless legs syndrome in childhood

, 2004
The diagnostic criteria of restless legs syndrome were defined in 1995 by the International Restless Legs Syndrome Study Group (IRLSSG). In light of the latest scientific evidence and increasing clinical experience the diagnostic criteria were revised in
Scholle, S., Happe, Svenja, Trenkwalder, Claudia, Hornyak, Magdolna, Schluter, B., Kinkelbur, J.   +5 more
core   +1 more source