Results 121 to 130 of about 36,469 (301)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
A discursive approach to relationship practices in classrooms: An exploratory study
, 2011 In today’s increasingly diverse classrooms it is well accepted that the relationship practices employed by teachers have consequences for the quality of the learning environment. Well chosen relationship practices are thought not only to help teachers to
Kecskemeti, Maria
core
, 2015 OBJECTIVES: This study was performed to investigate the effects of different intracanal medicaments on chemical structure and microhardness of dentin.
Hamdon, Ghaeth Yassen +2 more
core +1 more source
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Towards a restorative and liveable urban environment
, 2016 In post-disaster reconstruction process, the physical aspect, such as shelter, food, medical service, etc. always attract great attention, whereas the psychological impact, which is of great significance as well, is among the lower hierarchy (Pynes and ...
Hu, X. (author)
core
Reconsidering restorative environments for older adults:How the social context shapes restorative experiences [PDF]
In this rapidly ageing world, restorative experiences of older adults appear to be a relatively understudied yet critical area of research. Earlier studies showed that age-related changes in physical abilities, sensitivity to environmental stressors, and
Neven, Louis +2 more
core +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Restorative potential of greenspaces in noise-polluted environments (RESTORE)
Urban densification often entails an increase in noise burden and a reduction of green spaces. This exposes residents to more stress and impedes outdoor recreation. The RESTORE project investigated if and how far green spaces facilitate, and road traffic noise impedes restoration from stress. It followed a comprehensive research approach: i) laboratory
Tobias, Silvia +10 more
openaire +2 more sources
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Nature perception and positive emotions in urban forest parks enhance subjective well-being
Scientific ReportsWith the acceleration of urbanization around the world, city dwellers face increasing levels of work stress and mental health issues, which negatively impact their subjective well-being.
Zhengkang Bai +3 more
doaj +1 more source