Results 71 to 80 of about 36,469 (301)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Exploring the Impact of Daytime and Nighttime Campus Lighting on Emotional Responses and Perceived Restorativeness

Buildings
The quality of campus environments plays an important role in the mental health of college students. However, the impact of nighttime lighting in campus settings has received limited attention.
Xianxian Zeng, Bing Zhang, Shenfei Chen, Yi Lin, Antal Haans   +4 more
doaj   +1 more source

The effect of slight thinning of managed coniferous forest on landscape appreciation and psychological restoration

Progress in Earth and Planetary Science, 2017
We investigated the influence of slight thinning (percentage of woods: 16.6%, basal area: 9.3%) on landscape appreciation and the psychological restorative effect of an on-site setting by exposing respondents to an ordinarily managed coniferous woodland.
Norimasa Takayama, Haruo Saito, Akio Fujiwara, Masahiro Horiuchi   +3 more
doaj   +1 more source

Effects of nature on restorative and cognitive benefits in indoor environment

, 2023
This study investigates the effects of natural exposure in an indoor environment on restorative quality and cognitive ability. Thirty participants were shown nature at three different indoor sites: baseline, indoor (some vegetation), and semi-indoor (a ...
Brian Schermer, Schermer, Brian (author), Rhee, Jee Heon (author), Gisung Han, Jee Heon Rhee, Han, Gisung (author), Kyung Hoon Lee, So Yeon Park, Park, S.Y. (author), Lee, Kyung Hoon (author)   +9 more
core   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Effects of restorative environments on mental health and its cognitive neural mechanisms

Frontiers in Forests and Global Change
The well-established improvement effect of restorative environments on mental health has been demonstrated by numerous studies. However, there are relatively few related environmental neuroscience studies.
Peng Wang, Jingyuan Lin, Wuji Lin
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Attractive running environments for all? A cross-sectional study on physical environmental characteristics and runners’ motives and attitudes, in relation to the experience of the running environment

BMC Public Health, 2019
Background Running has become one of the most popular sports and has proven benefits for public health. Policy makers are increasingly aware that attractively designed public spaces may promote running. However, little is known about what makes a running
Ineke Deelen, Mark Janssen, Steven Vos, Carlijn B. M. Kamphuis, Dick Ettema   +4 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Designing Stress-Relieving Small Inner-City Park Environments for Teenagers

Land
All over the world, teenagers suffer from stress-related mental illness, and research shows that being in natural environments can bring about recovery.
Aida Nosrati, Mahdieh Pazhouhanfar, Chongxian Chen, Patrik Grahn   +3 more
doaj   +1 more source