Results 51 to 60 of about 100,093 (293)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

The Effectiveness of Restorative Justice Practices on Victims of Crime: Evidence from South Africa

International Journal for Crime, Justice and Social Democracy, 2021
Restorative justice is a holistic philosophy that has become increasingly popular in reformist criminal justice debates and criminological research. However, there is some debate as to whether its programs adequately address victims’ needs.
Patrick Bashizi Bashige Murhula, Aden Dejene Tolla   +1 more
doaj   +1 more source

Restorative Practices in Buffalo: Building and Rebuilding Community [PDF]

, 2018
Restorative practices/restorative justice (RP or RJ) is an alternative approach to our current punitive system of addressing conflict and crime. It is an age-old practice with origins in many indigenous cultures and has become increasingly popular in ...
Franco, Kathryn
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Restorative Justice: Pemaknaan, Problematika, dan Penerapan yang Seyogianya

Unes Journal of Swara Justisia
Pendekatan restorative justice merupakan tonggak pembaharuan reformasi sistem hukum pidana ke arah positif. Namun dewasa ini, sistem hukum pidana Indonesia belum mengakomodasi penjelasan secara komprehensif mengenai definisi, prinsip, serta penerapan ...
Muhammad Rif'an Baihaky, Muridah Isnawati   +1 more
doaj   +1 more source

The other voice in the room: restorative justice facilitators’ constructions of justice [PDF]

, 2014
Restorative justice represents an approach to managing conflict initiated by a wrongdoing that focuses on restoring the participants materially, psychologically, and relationally. Restorative interventions usually involve facilitators who act as “experts”
Dunlop, Julia A., Paul, Gregory D.
core   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Evaluation of the South Yorkshire Restorative Justice programme (SYRJP) [PDF]

, 2012
The SYRJP was developed in partnership between South Yorkshire Police and the Local Criminal Justice Board (LCJB) with the aim of implementing a county wide model of Restorative Justice (RJ) for use in neighbourhood policing and other community ...
Albertson, Katherine, Ellingworth, Daniel, Meadows, Linda, Senior, Paul   +3 more
core  

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source