Results 61 to 70 of about 1,131,741 (277)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

An Interdisciplinary Theoretical Interpretive Synthesis Examining the Barriers to Implementing Restorative Justice as the Standard Paradigm of Adult Criminal Justice Within the Context of the United States [PDF]

open access: yes, 2010
A systemic paradigm shift of any sort is complex and multifaceted. A systemic paradigm shift of justice is no different. The purpose of this study is to identify the barriers that exist in a systemic paradigm shift from retributive justice to restorative
Van Maastricht, Matthew J.   +1 more
core  

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim   +17 more
wiley   +1 more source

Criminal Problem Solving Model Through Restorative Justice Approach [PDF]

open access: yesKošická bezpečnostná revue, 2021
Restorative Justice is a solution which can be seen as fair treatment to all parties (win-win solutions). Nowadays, Restorative justice in Indonesia is still dealing with the conventional criminal justice system.
Karim
doaj  

The Essential Role of Human Service Nonprofits in Restorative Justice Policy Implementation

open access: yesNonprofit Policy Forum, 2023
Evidence demonstrating the essential role of human service nonprofits in restoring justice to communities has led to an increased need in understanding how these nonprofits view their service delivery role in relation to the state in a restorative ...
Moore Paige L., Lawrence Kara L.
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

Your Ways or Our Ways? Addressing Canadian Neo-Colonialism and Restorative Justice

open access: yesSalus Journal, 2019
In Canada, there is much focus on diversionary tactics and restorative justice programs designed to redirect offenders from the judicial processes and incarceration.
Dean Young
doaj  

RESTORATIVE JUSTICE AS AN ALTERNATIVE TO SETTLEMENT OF MISDEMEANOR CRIMES: A CASE STUDY

open access: yesJournal Presumption of Law
This article examines the utilization of restorative justice as an alternative to misdemeanor crimes in the criminal justice system at the Police sector Purwareja Klampok level.
Athif Hasan Al Banna   +2 more
doaj   +1 more source

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

REVIEW OF ISLAMIC CRIMINAL LAW ON THE SETTLEMENT OF MOTORCYCLE EMBEZZLEMENT CASES THROUGH RESTORATIVE JUSTICE

open access: yesTa'zir
The settlement of motorcycle embezzlement cases that occur in the community is usually resolved through litigation, but as the times develop, the case is resolved through the restorative justice mechanism.
Ilal Amri   +2 more
doaj   +1 more source

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