Results 41 to 50 of about 2,720,038 (247)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Noninvasive gene delivery to foveal cones for vision restoration [PDF]

JCI Insight, 2018
Intraocular injection of adeno-associated viral (AAV) vectors has been an evident route for delivering gene drugs into the retina. However, gaps in our understanding of AAV transduction patterns within the anatomically unique environments of the subretinal and intravitreal space of the primate eye impeded the establishment of noninvasive and efficient ...
Khabou, Hanen, Garita-Hernandez, Marcela, Chaffiol, Antoine, Reichman, Sacha, Jaillard, Céline, Brazhnikova, Elena, Bertin, Stephane, Forster, Valérie, Desrosiers, Mélissa, Winckler, Céline, Goureau, Olivier, Picaud, Serge, Duebel, Jens, Sahel, José-Alain, Dalkara, Deniz   +14 more
openaire   +3 more sources

Restoration of bacterioopsin gene expression in a revertant of Halobacterium halobium [PDF]

Journal of Bacteriology, 1985
Restoration of bacterioopsin (bop) gene expression in a revertant of Halobacterium halobium was investigated. The phenotype of the revertant is the result of a translocation of the 588-base-pair (bp) sequence "ISH25", adjacent to an ISH24 insertion found in the parental mutant IV-4.
F A, Pfeifer, H W, Boyer, M C, Betlach
openaire   +2 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Allelic relationship between restorer genes for A1 and A4 CMS systems in pearl millet [PDF]

, 2017
Understanding the allelic complementation of restoration among the stable restorer lines will contribute to robust pearl millet restorer breeding program. Thus, present study aimed to test allelic relationship between four diverse restorer lines each for
Atkari, D, S. K. Gupta, Gupta, S K, D. Yadav, M. Govindaraj, Yadav, D, K. N. Rai, D. Atkari, Rai, K N, Govindaraj, M   +9 more
core   +1 more source

Identification of fertility restoration candidate genes from a restorer line R186 for Gossypium harknessii cytoplasmic male sterile cotton

BMC Plant Biology, 2023
Background The utilization of heterosis based on three-line system is an effective strategy in crop breeding. However, cloning and mechanism elucidation of restorer genes for cytoplasmic male sterility (CMS) in upland cotton have yet been realized ...
Cheng Cheng, Hushuai Nie, Huijing Li, Daniel Adjibolosoo, Bin Li, Kaiyun Jiang, Yanan Cui, Meng Zhu, Baixue Zhou, Anhui Guo, Jinping Hua   +10 more
doaj   +1 more source

Improving gene quantification by adjustable spot-image restoration [PDF]

Bioinformatics, 2007
AbstractMotivation: One of the major factors that complicate the task of microarray image analysis is that microarray images are distorted by various types of noise. In this study a robust framework is proposed, designed to take into account the effect of noise in microarray images in order to assist the demanding task of microarray image analysis. The
Antonis Daskalakis, Dionisis A. Cavouras, Panagiotis Bougioukos, Spiros Kostopoulos, Dimitris Glotsos, Ioannis Kalatzis, George C. Kagadis, Christos Argyropoulos, George Nikiforidis   +8 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Genome-Wide Dissection of Quan 9311A Breeding Process and Application Advantages

Rice Science, 2023
Germplasm resource innovation is a crucial factor for cultivar development, particularly within the context of hybrid rice breeding based on the three-line system.
Li Qianlong, Feng Qi, Wang Heqin, Kang Yunhai, Zhang Conghe, Du Ming, Zhang Yunhu, Wang Hui, Chen Jinjie, Han Bin, Fang Yu, Wang Ahong   +11 more
doaj   +1 more source