Results 41 to 50 of about 178,886 (297)

The efficiency of designs for fine-mapping of quantitative trait loci using combined linkage disequilibrium and linkage

Genetics Selection Evolution, 2004
In a simulation study, different designs were compared for efficiency of fine-mapping of QTL. The variance component method for fine-mapping of QTL was used to estimate QTL position and variance components.
Werf Julius, Lee Sang
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Appendix A. Restricted maximum-likelihood estimates for morphological traits.

, 2016
Restricted maximum-likelihood estimates for morphological ...
Amanda Gibson (300206), Larry Douglass (2914820), Courtney J. Murren (2914823), Michele R. Dudash (2913239)   +3 more
core   +1 more source

Multilevel Analysis of Wage Inequality in Palestine [PDF]

Statistika: Statistics and Economy Journal, 2019
Historical data exhibit the imbalance participation rate between genders in the Palestinian labour market in which female participation is among the lowest worldwide.
Mohsen Ayyash, Sek Siok Kun
doaj  

Comparison of genetic parameter evaluation methods for body mass of the five-week-old layer

浙江大学学报. 农业与生命科学版, 2019
This study aimed to investigate the selection potential for early body mass in a layer resource population, and to compare three inference methods based on their efficiency and accuracy, including restricted maximum likelihood method (REML), Markov chain
GUO Jun, QU Liang, DOU Taocun, SHEN Manman, HU Yuping, WANG Kehua   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

An introduction to pspatreg

REGION, 2022
This article introduces a new R package (pspatreg) for the estimation of semiparametric spatial autoregressive models. pspatreg fits penalized spline semiparametric spatial autoregressive models via Restricted Maximum Likelihood or Maximum Likelihood ...
Román Mínguez, Roberto Basile, María Durbán   +2 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Statistical Genetic Discoveries Using Restricted Maximum Likelihood Method

, 2022
In statistical genetics, genetic association and genomic prediction become more successful with a highly heritable trait. Identifying highly heritable components of a complex disease can thus advance scientific understanding of the disease and ...
Wu, Erika
core   +1 more source