Results 131 to 140 of about 19,206,393 (242)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Long-term efficacy of traditional Chinese medicine combined with chemotherapy for advanced non-small cell lung cancer: a systematic review and meta-analysis of reconstructed individual patient data over 3 years

Frontiers in Pharmacology
IntroductionTo evaluate the 3-year efficacy of combining traditional Chinese medicine with chemotherapy in the treatment of advanced non-small cell lung cancer, taking into account time-dependent survival effects.MethodsA systematic review and meta ...
Yixuan Guo, Dan Wang, Xuexiu Jia
doaj   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Summarizing and communicating on survival data according to the audience: a tutorial on different measures illustrated with population-based cancer registry data

Clinical Epidemiology, 2019
Aurélien Belot, Aminata Ndiaye, Miguel-Angel Luque-Fernandez, Dimitra-Kleio Kipourou, Camille Maringe, Francisco Javier Rubio, Bernard Rachet Cancer Survival Group, Department of Non-Communicable Disease Epidemiology, Faculty of Epidemiology and ...
Belot A, Ndiaye A, Luque-Fernandez MA, Kipourou DK, Maringe C, Rubio FJ, Rachet B   +6 more
doaj  

Completion of ≥6 cycles of adjuvant temozolomide is the strongest modifiable prognostic factor in glioblastoma: a 17-year real-world cohort of 319 glioma patients from a single Chinese center

Frontiers in Oncology
BackgroundLevel-1 evidence supports adjuvant temozolomide (TMZ) after chemoradiotherapy in newly diagnosed glioblastoma, but many patients discontinue before completing the six cycles the regimen calls for—particularly in China, where long-term outcome ...
Pei Liu, Xiaotang Xiao, Beiquan Hu, Kebei Xu, Ting Liu, Xu Liu, Huixian Huang, Qiang Pang, Zhiping Lu, Defeng Qing, Yu Liang, Siting Lin, Hao Chen, Heming Lu   +13 more
doaj   +1 more source

R_codes – Supplemental material for Design and monitoring of survival trials based on restricted mean survival times

, 2019
Supplemental material, R_codes for Design and monitoring of survival trials based on restricted mean survival times by Xiaodong Luo, Bo Huang and Hui Quan in Clinical ...
Xiaodong Luo (2020372), Bo Huang (30906), Hui Quan (391814)   +2 more
core   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

A phase I/II randomized controlled clinical trial to assess the feasibility, safety, and preliminary effectiveness of paracetamol in resolving acute kidney injury in children with severe malaria

Trials
Background Acute kidney injury (AKI) is prevalent among children with severe malaria, contributing to considerable morbidity and mortality. Oxidative stress has been implicated in the pathophysiology of malaria-induced AKI, and paracetamol, with its ...
George Paasi, Cate Namayanja, Paul Ongodia, Charles Benard Okalebo, William Okiror, Grace Abongo, George Masifa, Denis Amorut, Rita Muhindo, Peter Olupot-Olupot, the PARIST trial study group   +10 more
doaj   +1 more source

Frailty phenotype and long-term mortality after curative colorectal cancer surgery: a retrospective multicenter cohort study

Frontiers in Oncology
BackgroundFrailty is associated with poor short-term surgical outcomes, but whether the Fried frailty phenotype is associated with long-term mortality after curative colorectal cancer (CRC) surgery, independently of age and tumor stage, is uncertain.
Yuxiao Xia, Minghui Li, Yuanling Zeng, Xiao Hu, Dan Zhou, Yiqun Guo, Meng Zou, Xuewei Yang, Fang Chen, Wei Wang   +9 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source