Results 81 to 90 of about 19,206,393 (242)

An application of restricted mean survival time in a competing risks setting: comparing time to ART initiation by injection drug use

BMC Medical Research Methodology, 2018
Background Restricted mean survival time (RMST) is an underutilized estimand in time-to-event analyses. Herein, we highlight its strengths by comparing time to (1) all-cause mortality and (2) initiation of antiretroviral therapy (ART) for HIV-infected ...
Keri L. Calkins, Chelsea E. Canan, Richard D. Moore, Catherine R. Lesko, Bryan Lau   +4 more
doaj   +1 more source

Uses and Limitations of the Restricted Mean Survival Time: Illustrative Examples From Cardiovascular Outcomes and Mortality Trials in Type 2 Diabetes

Annals of Internal Medicine, 2020
The restricted mean survival time (RMST) has been advocated as an alternative or a supplement to the hazard ratio for reporting the effect of an intervention in a randomized clinical trial. The RMST difference allows quantification of the postponement of
D. Kloecker, M. Davies, K. Khunti, F. Zaccardi   +3 more
semanticscholar   +1 more source

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Estimation of change-point in the covariate effects on restricted mean survival time

Communications in Statistics - Theory and Methods
The restricted mean survival time (RMST) emerges as a crucial summary metric in survival analysis. In some cases, certain covariates may have a varying impact on RMST at one specific change-point. For instance, consider studies focusing on women’s health,
Xiaoran Yang, Fangfang Bai
semanticscholar   +1 more source

Choosing the Cut Point for a Restricted Mean in Survival Analysis, a Data Driven Method [PDF]

, 2013
Survival Analysis generally uses the median survival time as a common summary statistic. While the median possesses the desirable characteristic of being unbiased, there are times when it is not the best statistic to describe the data at hand.
Sheldon, Emily H
core   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Long-term adult congenital heart disease survival after heart transplantation: A restricted mean survival time analysis.

, 2021
BACKGROUND: Adult Congenital Heart Disease (ACHD) heart transplant recipients may have lower post-transplant survival resulting from higher peri-operative mortality than non-ACHD patients.
Dolgner, Stephen J, Krieger, Eric V, Dardas, Todd F, Nguyen, Vidang P, Stempien-Otero, April   +4 more
core   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Survival outcomes of population-wide colonoscopy screening: reanalysis of the NordICC data

BMC Gastroenterology
Background Colonoscopy as a common screening practice to prevent colorectal cancer lacks strong evidence. NordICC, the first randomized trial of colonoscopy screening, reported no clear clinical benefit for colonoscopy in the intention-to-screen ...
Tomer Meirson, Gal Markel, Daniel A. Goldstein   +2 more
doaj   +1 more source