Results 101 to 110 of about 142,506 (314)

Stability-Diversity Tradeoffs Impose Fundamental Constraints on Selection of Synthetic Human VH/VL Single-Domain Antibodies from In Vitro Display Libraries

Frontiers in Immunology, 2017
Human autonomous VH/VL single-domain antibodies (sdAbs) are attractive therapeutic molecules, but often suffer from suboptimal stability, solubility and affinity for cognate antigens.
Kevin A. Henry, Dae Young Kim, Hiba Kandalaft, Michael J. Lowden, Qingling Yang, Joseph D. Schrag, Greg Hussack, C. Roger MacKenzie, C. Roger MacKenzie, Jamshid Tanha, Jamshid Tanha, Jamshid Tanha   +11 more
doaj   +1 more source

Construction of hyperthermostable d‐allulose 3‐epimerase from Arthrobacter globiformis M30 using the sequence information from Arthrobacter psychrolactophilus

FEBS Open Bio, EarlyView.
d‐Allulose can be produced from d‐fructose by d‐allulose 3‐epimerase. Based on sequence homology information, we successfully engineered thermostable mutants with the protein engineering method. By integrating positive mutations, we constructed an enzyme that exhibits hyperthermostability without a loss in the activity.
Kensaku Shimada, Kouhei Ohtani, Pushpa Kiran Gullapalli, Kazuhiko Ishikawa   +3 more
wiley   +1 more source

Serum vitamin C levels and risk of osteoporosis: results from a cross-sectional study and Mendelian randomization analysis

Hereditas
Background The role of vitamin C as an antioxidant in guarding against osteoporosis in adults is still debated. This research employs both a cross-sectional study and a two-sample bidirectional Mendelian randomization (MR) analysis to explore how serum ...
Zhiwen Liu, Zijing Peng, Yelin Zhong, Jianjun Wu, Sicheng Xiong, Wei Zhong, Jiehua Luo, Zhihai Zhang, Hongxing Huang   +8 more
doaj   +1 more source

PCGOD: Enhancing Object Detection With Synthetic Data for Scarce and Sensitive Computer Vision Tasks

IEEE Access
Object detection models rely on large-scale, high-quality annotated datasets, which are often expensive, scarce, or restricted due to privacy concerns.
Walid Remmas, Martin Lints, Jaak Joonas Uudmae   +2 more
doaj   +1 more source

Advantages and limitations of navigation‐based multicriteria optimization (MCO) in selectively sparing pharyngeal constrictor muscles in head and neck radiotherapy treatment planning

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Sparing pharyngeal constrictor muscles (PCMs) during radiotherapy improves patient‐reported swallowing function. This study aimed to explore the feasibility of integrating knowledge‐based planning (KBP) with multicriteria optimization (MCO) in Eclipse v18.0 to selectively spare PCM, quantify the required trade‐off in prophylactic ...
Laura K. Howard, Simon J. P. Meara, Ehab M. Ibrahim, Carl G. Rowbottom   +3 more
wiley   +1 more source

Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and serum thyroid function measures: Recent Findings from NHANES 2007–2012 and Mendelian randomization

Frontiers in Endocrinology
ObjectiveThere is limited epidemiological data regarding the association of blood lipids with thyroid hormones. Thus, the present article aims to explore whether there is an association between non-high-density to high-density lipoprotein cholesterol ...
Mo-Yao Tan, Ping Zhang, Shan Wu, Si-Xuan Zhu, Ming Gao   +4 more
doaj   +1 more source

Linear mixed models with endogenous covariates: modeling sequential treatment effects with application to a mobile health study

, 2019
Mobile health is a rapidly developing field in which behavioral treatments are delivered to individuals via wearables or smartphones to facilitate health-related behavior change.
Klasnja, Predrag, Murphy, Susan A., Qian, Tianchen   +2 more
core  

UR‐cycleGAN: Denoising full‐body low‐dose PET images using cycle‐consistent Generative Adversarial Networks

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to develop a CycleGAN based denoising model to enhance the quality of low‐dose PET (LDPET) images, making them as close as possible to standard‐dose PET (SDPET) images. Methods Using a Philips Vereos PET/CT system, whole‐body PET images of fluorine‐18 fluorodeoxyglucose (18F‐FDG) were acquired from 37 patients to ...
Yang Liu, ZhiWu Sun, HaoJia Liu
wiley   +1 more source

Restricted Maximum Likelihood to estimate variance components for mixed models with two random factors [PDF]

, 1987
Karin Meyer
openalex   +1 more source

Localization accuracy of 6‐second CBCT for lung IGRT with various breathing patterns

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose The 6‐second cone beam computed tomography (CBCT) acquisition of the Ethos HyperSight (Varian Medical Systems, Inc. Palo Alto, CA, USA) on‐board imaging system offers benefits, but could be too fast to accurately capture an average target position in a free‐breathing lung cancer patient. This study aimed to ascertain whether a 6‐second
Jihye Koo, Gage Redler, Vladimir Semenenko, Stephen A. Rosenberg, Emily Keit, Jacqueline M. Andreozzi   +5 more
wiley   +1 more source