Results 211 to 220 of about 10,132,911 (226)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Effects of mutations in phage restriction sites during escape from restriction–modification

Biology Letters, 2017
Restriction–modification systems are widespread genetic elements that protect bacteria from bacteriophage infections by recognizing and cleaving heterologous DNA at short, well-defined sequences called restriction sites. Bioinformatic evidence shows that
Călin C Guet, Maroš Pleška
exaly   +2 more sources

Organization of restriction-modification systems.

Nucleic Acids Research, 1991
The genes for over 100 restriction-modification systems have now been cloned, and approximately one-half have been sequenced. Despite their similar function, they are exceedingly heterogeneous.
Geoffrey G Wilson
exaly   +1 more source

Restriction endonucleases and modification methylases

Current Opinion in Structural Biology, 1993
Restriction endonucleases and modification methylases offer excellent systems for studying protein-DNA interactions. The past year has seen the experimental verification of some aspects of the catalytic mechanisms of both types of enzyme.
Anderson, J. E.
exaly   +2 more sources

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Evolution of Restriction–Modification Systems Consisting of One Restriction Endonuclease and Two DNA Methyltransferases

Biochemistry (Moscow), 2023
Andrei Alexeevski, Anna Karyagina, Sergei Spirin   +2 more
exaly  

Phase-variable methylation and epigenetic regulation by type I restriction-modification systems.

FEMS Microbiology Reviews, 2017
Nicholas J Croucher, Megan De Ste Croix, Stephen D Bentley   +2 more
exaly  

Role of restriction-modification systems in prokaryotic evolution and ecology

Biochemistry (Moscow), 2015
Andrei Alexeevski, Anna Karyagina, Sergei Spirin   +2 more
exaly  

Systems Biology of Bacterial Immune Systems: Regulation of Restriction-Modification and CRISPR-Cas Systems

RNA Technologies, 2018
Marko Djordjevic, Bojana Blagojevic, Andjela Rodic   +2 more
exaly  

Restriction–modification systems may be associated with Helicobacter pylori virulence

Journal of Gastroenterology and Hepatology (Australia), 2010
Ryoji Miyahara, Kazuhiro Ishiguro, Nobuyuki Miyake   +2 more
exaly