Results 91 to 100 of about 3,021,567 (290)
Discrete Mathematics, 2001 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
George E. Andrews, Richard P. Lewis 0001
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Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
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Advances in Applied Mathematics, 2011 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
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Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction
Cell Reports, 2017 Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an
Patricia Domingues, Benjamin G. Hale
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FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
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Central European Journal of Geography and Sustainable DevelopmentWithin the framework of this paper, we proposed to analyze the evolution of demand for this destination during the restrictions generated by COVID 19, but also the interest of investors in this area.
Mihaela-Iuliana Desculțu Grigore +2 more
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Herz, 2006 The group of restrictive cardiomyopathies (RKMP) includes a number of myocardial and endomyocardial diseases. These entities are characterized by stiffening of both ventricles resulting in a deterioration of ventricular filling and severe diastolic dysfunction. Systolic ventricular function is usually normal or only mildly impaired.
Wachter, R. Rolf, Pieske, Burkert M.
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In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
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FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
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