Results 81 to 90 of about 1,374,642 (248)

The market acceptance and welfare impacts of genetic use restriction technologies (GURTS) [PDF]

The paper develops a theoretical framework of heterogeneous consumers and producers to examine the market and welfare effects of the introduction of variety-level genetic use restriction technologies (V-GURTs) under the current No-Labeling regime of GMPs
Yiannaka, Amalia, Khachaturyan, Marianna
core   +2 more sources

Comprehensive Review of Human Plasmodium falciparum-Specific CD8+ T Cell Epitopes

Frontiers in Immunology, 2019
Control of malaria is an important global health issue and there is still an urgent need for the development of an effective prophylactic vaccine. Multiple studies have provided strong evidence that Plasmodium falciparum-specific MHC class I-restricted ...
Janna Heide, Janna Heide, Kerrie C. Vaughan, Alessandro Sette, Alessandro Sette, Thomas Jacobs, Julian Schulze zur Wiesch, Julian Schulze zur Wiesch   +7 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Establishing a role for specific nutrients in Drosophila dietary restriction [PDF]

, 2009
Dietary restriction (DR), the reduction in food intake that falls short of starvation, has been shown to be the most robust and reproducible intervention to extend lifespan in diverse organisms ranging from yeast to mammals, including the fruit fly ...
Grandison, R.
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Conformational adaptation of Asian macaque TRIMCyp directs lineage specific antiviral activity [PDF]

, 2010
TRIMCyps are anti-retroviral proteins that have arisen independently in New World and Old World primates. All TRIMCyps comprise a CypA domain fused to the tripartite domains of TRIM5α but they have distinct lentiviral specificities, conferring HIV-1 ...
Ylinen, L.M.J., Ylinen, LMJ, Greg J Towers, Hué, S., Marzetta, F, Laura M J Ylinen, Flavia Marzetta, Rose, NJ, Towers, G.J., Rose, N.J., Marzetta, Flavia, Hué, Stéphane, Leo C James, Rose, Nicola J, Price, A.J., Nicola J Rose, Amanda J. Price, James, L.C., Stéphane Hué, Price, Amanda J, Rasaiyaah, Jane, Marzetta, F., Towers, Greg J, Rasaiyaah, J., Laura M. J. Ylinen, Amanda J Price, Ylinen, Laura MJ, Jane Rasaiyaah, Greg J. Towers, Price, AJ, James, LC, Rasaiyaah, J, Nicola J. Rose, James, Leo C, Towers, GJ, Hue, S, Leo C. James   +36 more
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Functional Insights into ANP32A-Dependent Influenza A Virus Polymerase Host Restriction

Cell Reports, 2017
Host restriction of influenza A virus limits pandemic emergence. The viral RNA polymerase (vPol) is an essential enzyme that must adapt for avian viruses to replicate in humans. Species differences in host ANP32A dictate adaptation: human ANP32A lacks an
Patricia Domingues, Benjamin G. Hale
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Structural and mutagenic analysis of the RM controller protein C.Esp1396I [PDF]

, 2014
Bacterial restriction-modification (RM) systems are comprised of two complementary enzymatic activities that prevent the establishment of foreign DNA in a bacterial cell: DNA methylation and DNA restriction.
Martin, Richard N. A., Kneale, Geoff, John E McGeehan, Geoff Kneale, Geoff Kneale (22086), Mcgeehan, John, Richard N A Martin, Richard N. A. Martin (571238), John E. McGeehan (431702)   +8 more
core   +2 more sources