Results 141 to 150 of about 2,984,053 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Prevalence and Prognostic Significance of Restriction Versus Systolic Dysfunction in Patients With Transthyretin and Light Chain Cardiac Amyloidosis. [PDF]

Circ Heart Fail
Zampieri M, Biagioni G, Del Franco A, Canepa M, Porto I, Zanoletti M, Labate ME, Porcari A, Bordignon L, Merlo M, Sinagra G, Tini G, Musumeci B, Barbato E, Autore C, Biagini E, Longhi S, Sena G, Ponziani A, Saturi G, Fico V, Argirò A, Mazzoni C, Fumagalli C, Olivotto I, Perfetto F, Cappelli F.   +26 more
europepmc   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Methionine restriction provides sex-specific protection against high-fat diet-induced adiposity, peripheral insulin resistance, and neuroinflammation in FGF21-dependent and independent manners in mice. [PDF]

PLoS One
Lail H, Lawrence R, Pinheiro F, Price E, Wanders D.   +4 more
europepmc   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Effects of sleep restriction on cognitive and physical performance in elite karate athletes: A randomized crossover study. [PDF]

Medicine (Baltimore)
Amri A, Faleh J, Ben Aissa M, Ceylan Hİ, Ben Hassen S, Hmaidi J, Guelmami N, Dergaa I, Ștefănică V, Souissi N.   +9 more
europepmc   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Short-term sleep restriction in humans alters diurnal circulating metabolite profiles, including those of microbial origin. [PDF]

J Clin Invest
Leone VA, Frazier K, Kaur M, Chrisler EA, Sidebottom AM, Tai E, Tran V, Li S, Chang EB, Jones DP, Van Cauter E, Hanlon EC.   +11 more
europepmc   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Association between nutrition literacy and hypertension control: chain mediating association of diet-control intention and salt-restriction tools utilization. [PDF]

Front Nutr
Zhang B, Yin W, Liu R, Liu H.
europepmc   +1 more source