Results 121 to 130 of about 2,927,400 (332)

Detecting homologous recombination deficiency for breast cancer through integrative analysis of genomic data

Molecular Oncology, EarlyView.
This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu, Katherine Eason, Suet‐Feung Chin, Paul A. W. Edwards, Raquel Manzano Garcia, Richard Moulange, Jia Wern Pan, Soo Hwang Teo, Sach Mukherjee, Maurizio Callari, Carlos Caldas, Stephen‐John Sammut, Oscar M. Rueda   +12 more
wiley   +1 more source

Conversion of barley SNPs into PCR-based markers using dCAPS method

Genetics and Molecular Biology, 2009
Molecular genetic research relies heavily on the ability to detect polymorphisms in DNA. Single nucleotide polymorphisms (SNPs) are the most frequent form of DNA variation in the genome.
Fahimeh Shahinnia, Badraldin Ebrahim Sayed-Tabatabaei   +1 more
doaj  

The use of phosphorothioate-modified DNA in restriction enzyme reactions to prepare nicked DNA [PDF]

, 1985
John W. Taylor, Walter Schmidt, Richard Cosstick, And̀rzej Okruszek, Fritz Eckstein   +4 more
openalex   +1 more source

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

RESTRICTION ENDONUCLEASE ANALYSIS OF PASTEURELLA MULTOCIDA FIELD ISOLATES BY Hha-I [PDF]

Pakistan Veterinary Journal, 2006
In this study the restriction endonuclease analysis (REA) technique was used for the comparison of field isolates and vaccinal strain of Pasteurella multocida using Hha-I enzyme.
R. MUNIR, U. FAROOQ, N. BADAR, A. KHANUM1 AND A. WADOOD1
doaj  

Quantification of Unmethylated Insulin DNA Using Methylation Sensitive Restriction Enzyme Digital Polymerase Chain Reaction. [PDF]

Transpl Int, 2022
van de Leemkolk FEM, Nell RJ, Versluis M, de Koning EJP, Huurman VAL, Alwayn IPJ, Ploeg RJ, van der Velden PA, Engelse MA.   +8 more
europepmc   +1 more source

EVOLUTIONARY RELATIONSHIPS AMONG FIVE SUBSPECIES OF MUS MUSCULUS BASED ON RESTRICTION ENZYME CLEAVAGE PATTERNS OF MITOCHONDRIAL DNA [PDF]

, 1981
Hiromichi Yonekawa, Kazuo Moriwaki, Osamu Gotoh, Jun‐Ichi Hayashi, Junko Watanabe, Nobumoto Miyashita, Michael L. Petras, Yusaku Tagashira   +7 more
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

RESCOT: Restriction Enzyme Set and Combination Optimization Tools for rNMP Capture Techniques. [PDF]

Theor Comput Sci, 2021
Xu P, Storici F.
europepmc   +1 more source

The effect of site-specific methylation on restriction-modification enzymes [PDF]

, 1987
Michael Nelson, Michael McClelland
openalex   +1 more source