Results 91 to 100 of about 610,827 (332)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

open access: yesFEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke   +2 more
wiley   +1 more source

Physical Mapping of the Magnaporthe grisea AVR1-MARA Locus Reveals the Virulent Allele Contains Two Deletions

open access: yesMolecular Plant-Microbe Interactions, 1997
The avirulence genes that have been identified in Magna-porthe grisea exhibit varying degrees of stability in infection assays. AVR1-MARA is considered one of the stable avirulence genes.
M. Alejandra Mandel   +4 more
doaj   +1 more source

A working model for cytoplasmic assembly of H/ACA snoRNPs

open access: yesFEBS Letters, EarlyView.
Dyskerin is the component of nuclear H/ACA ribonucleoproteins (RNPs) endowed with pseudouridine synthase catalytic activity. Two isoforms of human dyskerin have been characterized: the abundant Iso1, mainly nuclear, and the shorter Iso3, mainly cytoplasmic but occasionally imported into nuclei.
Alberto Angrisani, Maria Furia
wiley   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

open access: yesFEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer   +10 more
wiley   +1 more source

AGORA: Assembly Guided by Optical Restriction Alignment

open access: yesBMC Bioinformatics, 2012
Background Genome assembly is difficult due to repeated sequences within the genome, which create ambiguities and cause the final assembly to be broken up into many separate sequences (contigs).
Lin Henry C   +6 more
doaj   +1 more source

Fock spaces corresponding to positive definite linear transformations

open access: yes, 2003
Suppose $A$ is a positive real linear transformation on a finite dimensional complex inner product space $V$. The reproducing kernel for the Fock space of square integrable holomorphic functions on $V$ relative to the Gaussian measure $d\mu_A(z)=\frac ...
Fabec, R., Olafsson, G., Sengupta, A.
core   +1 more source

Linear representations of hyperelliptic mapping class groups

open access: yes, 2020
Let $p:S\to S_g$ be a finite $G$-covering of a closed surface of genus $g\geq 1$ and let $B$ its branch locus. To this data, it is associated a representation of a finite index subgroup of the mapping class group $\operatorname{Mod}(S_g\smallsetminus B)$
Boggi, Marco
core  

Locating Restricted Facilities on Binary Maps

open access: yes, 2008
In this paper we consider several facility location problems with applications to cost and social welfare optimization, when the area map is encoded as a binary (0,1) mxn matrix. We present algorithmic solutions for all the problems. Some cases are too particular to be used in practical situations, but they are at least a starting point for more ...
Mugurel Ionut Andreica   +2 more
openaire   +4 more sources

Novel and unscrutinized immune entities of the zebrafish gut

open access: yesFEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil   +5 more
wiley   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

open access: yesFEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona   +4 more
wiley   +1 more source

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