Results 131 to 140 of about 366,961 (337)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The position of parliament in state of emergency and state of war within constitutional system of the Republic Of Serbia [PDF]

NBP: Nauka, bezbednost, policija, 2015
State of emergency is a specific form of state of emergency in which there is a state due to the occurrence of unexpected and difficult circumstances for the survival of the property and citizens.
Jovičić Jelena
doaj  

MEASURES TO ENSURE PROCEEDINGS IN ADMINISTRATIVE OFFENSES THAT RESTRICT PROPERTY RIGHTS

Naukovyy Visnyk Dnipropetrovs kogo Derzhavnogo Universytety Vnutrishnikh Sprav
In Ukraine, there are many administrative and legal tools for law enforcement, protection of citizens’ rights and interests, in which the special place is taken by measures of ensuring proceedings in cases of administrative offenses. Their application implements the termination of administrative misconduct, identification of the offender, drawing up a ...
Andriy SOBAKAR, Oksana MYSLYVA
openaire   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Jam for Justice Holmes: Reassessing the Significance of \u3ci\u3eMahon\u3c/i\u3e [PDF]

, 1998
When courts and commentators discuss Pennsylvania Coal Co. v. Mahon, they use the same word with remarkable regularity: famous. Mahon has achieved this fame in part because it was the occasion for conflict between judicial giants, and because the result ...
Treanor, William Michael
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

The development of digital tourism in China

Cogent Social Sciences
Under the tide of information and globalization, modern information technologies such as computers, the Internet, mobile communications, the Internet of Things, big data, artificial intelligence, and virtual reality are developing rapidly, and the ...
Li Ying, Qiu Ziyi, Hao Shizhuan, Li Yan, Zou Tongqian   +4 more
doaj   +1 more source

The Clash of Agricultural Exceptionalism and the First Amendment: A Discussion of Kansas\u27 Ag-Gag Law [PDF]

, 2019
Since the Nation’s founding, agricultural production has been treated differently than other industries. This concept, known as “agricultural exceptionalism,” has manifested in many different ways throughout U.S. history.
Kaufman, Meredith
core   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

THE RESTRICTION ON THE RIGHT TO RURAL PROPERTY DUE TO THE DUMPING OF ITS SOCIAL FUNCTION

, 2018
The objective of this research was to analyze the right of rural property in accordance with current legislation, taking into account the social function of the property and its connection with the environmental issue, especially with regard to the right to the environment ecologically balanced. It was analyzed the right of the owner who, in principle,
POZZETTI, VALMIR CÉSAR, SOUSA, TÂMARA MENDES GONÇALVES DE   +1 more
openaire   +1 more source