Results 181 to 190 of about 6,061,790 (368)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Having a Same Type IIS Enzyme's Restriction Site on Guide RNA Sequence Does Not Affect Golden Gate (GG) Cloning and Subsequent CRISPR/Cas Mutagenesis. [PDF]

Int J Mol Sci, 2022
Moniruzzaman M, Zhong Y, Huang Z, Zhong G.   +3 more
europepmc   +1 more source

RsrII-a novel restriction endonuclease with a heptanucleotide recognition site [PDF]

, 1984
C. David O′Connor, E S Metcalf, Christopher J. Wrighton, Tim Harris, J. R. Saunders   +4 more
openalex   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Integrating Sequence Capture and Restriction Site-Associated DNA Sequencing to Resolve Recent Radiations of Pelagic Seabirds. [PDF]

Syst Biol, 2021
Ferrer Obiol J, James HF, Chesser RT, Bretagnolle V, González-Solís J, Rozas J, Riutort M, Welch AJ.   +7 more
europepmc   +1 more source

The average spacing of restriction enzyme recognition sites in DNA [PDF]

, 1982
Gordon P. Moore, A. R. Moore
openalex   +1 more source

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?

Molecular Oncology, EarlyView.
Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley   +1 more source

ECONOMIC AND ENVIRONMENTAL BENEFITS OF VARIABLE RATE APPLICATION OF NITROGEN TO CORN FIELDS: ROLE OF VARIABILITY AND WEATHER [PDF]

The use of meta-response functions based on EPIC-generated data resulted in comparisons between variable (VRAT) and uniform rate application technologies for 36 simulated fields.
English, Burton C., Mahajanashetti, S.B., Roberts, Roland K.   +2 more
core   +1 more source

Genome-Wide Association Mapping of Virulence Genes in Wheat Karnal Bunt Fungus Tilletia indica Using Double Digest Restriction-Site Associated DNA-Genotyping by Sequencing Approach. [PDF]

Front Microbiol, 2022
Shakouka MA, Gurjar MS, Aggarwal R, Saharan MS, Gogoi R, Bainsla Kumar N, Agarwal S, Kumar TPJ, Bayaa B, Khatib F.   +9 more
europepmc   +1 more source

DNA cleavage by restriction endonucleasePflMl is inhibited in recognition sites modified bydcmmethylation [PDF]

, 1989
Richard A. Sturm, Peter Yaciuk
openalex   +1 more source