Results 171 to 180 of about 15,943 (285)

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos   +16 more
wiley   +1 more source

Impact of Increasing Referral for <sup>99m</sup>Tc-DPD Scintigraphy on Prognosis Across the Phenotypic Spectrum of Restrictive Cardiomyopathy. [PDF]

open access: yesJACC Adv
Choy CH   +17 more
europepmc   +1 more source

Restrictive Cardiomyopathy: Contemporary Insights into Pathophysiology, Diagnostic Complexity, and Evolving Therapeutic Perspectives

open access: hybrid
Universidad Universidad Cuauhtémoc Plantel Aguascalientes. Aguascalientes, Mexico.   +21 more
openalex   +2 more sources

Second‐generation prokineticin PKR1 receptor agonists: Advancing cardioprotection against chemotherapy‐induced toxicity

open access: yesBritish Journal of Pharmacology, EarlyView.
IS39, a novel non‐peptide PKR1 agonist, confers cardioprotection against doxorubicin‐induced toxicity. IS39 activates PKR1‐mediated pro‐survival signalling in cardiomyocytes, reducing reactive oxygen species (ROS), DNA damage and fibrosis markers. In vivo, IS39 preserves cardiac geometry and function in mice exposed to chronic doxorubicin challenge ...
Anais Audebrand   +8 more
wiley   +1 more source

A Volume Challenge Reveals the Diagnosis of Pediatric Restrictive Cardiomyopathy. [PDF]

open access: yesCase Rep Cardiol, 2022
Cohen E   +4 more
europepmc   +1 more source

Circulating Musclin is associated with skeletal muscle function and subclinical cardiac dysfunction in patients with cancer

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Musclin (osteocrin) is a skeletal muscle‐derived peptide that has been implicated in cardioprotective signalling pathways. Its relevance in cancer patients, who frequently experience muscle wasting and cardiotoxicity, remains unclear. This study aimed to determine whether circulating Musclin levels reflect functional capacity and
Jannek Brauer   +5 more
wiley   +1 more source

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