Results 111 to 120 of about 614,582 (348)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Le misure restrittive dell'Unione europea per sviamento di fondi pubblici alla luce della sentenza Azarov

European Papers, 2016
(Series Information) European Papers - A Journal on Law and Integration, 2016 1(2), 715-726 | European Forum Insight of 9 May 2016 | (Table of Contents) I. Le misure restrittive per sviamento di fondi pubblici. - II.
Sara Poli
doaj   +1 more source

How Laws Affect Contracts: Evidence from Yankee Bond Covenants [PDF]

We examine how country-level legal and institutional differences in creditor and shareholder rights shape the use of bond covenants. Using comprehensive debt covenant information for a sample of Yankee bonds issued by firms from more than 50 countries ...
John Wald, Lukas Roth, Yaxuan Qi
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

The Triple "S" Impact of COVID-19: Nationwide Evidence of the Impact of the Stress Associated With Restrictive Measures on Substance Use, Sleep, and Social Connectedness in Qatar. [PDF]

J Psychiatr Pract, 2023
Abed Alah M, Abdeen S, Kehyayan V, Bougmiza I.   +3 more
europepmc   +1 more source

Analysis with SARIMA and FFT Between Two Neighboring Cities Regarding the Implementation of Restrictive Lockdown Measures

, 2022
Dunfrey Pires Aragão, Davi Henrique dos Santos, Adriano Mondini, Cosimo Distante, Luiz Marcos Garcia Gonçalves   +4 more
openalex   +2 more sources

Disentangling Market Access Effects of Preferential Trading Arrangements Application for ASEAN Members under an ASEAN-EU FTA [PDF]

The paper develops two synthetic measures at the HS-10 level to depict effective market access for a country receiving preferential access and applies these to the market access ASEAN members would receive on impact following the implementation of an FTA
Bolormaa TUMURCHUDUR, Céline CARRERE, Jaime MELO DE   +2 more
core  

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Obstetric and Gynecological Admissions and Hospitalizations in an Italian Tertiary-Care Hospital during COVID-19 Pandemic: A Retrospective Analysis According to Restrictive Measures. [PDF]

J Clin Med, 2023
Riemma G, De Franciscis P, Tesorone M, Coppa E, Schiattarella A, Billone V, Lopez A, Cucinella G, Gullo G, Carotenuto RM.   +9 more
europepmc   +1 more source