Results 131 to 140 of about 616,172 (304)

Increases in consumption and harms among young people in the context of alcohol policy liberalisation : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Public Health at Massey University, Albany, New Zealand [PDF]

open access: yes, 2011
Objective: To assess drinking patterns and alcohol-related harms among young people in the context of substantial liberalising alcohol policy change in New Zealand.
Huckle, Taisia
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

On the Prudence of Rewarding A While Hoping for B [PDF]

open access: yes
In multiple-task hidden-action models, the (mis-)allocation of effort may play an important role for benefit creation. Signals which capture this benefit and which are used in incentive schemes should thus not only be judged by the noise and the ...
Wendelin Schnedler
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Services in Doha : what's on the table ? [PDF]

open access: yes
Services trade reform matters, but what is Doha doing about it? It has been hard to judge, because of the opaqueness of services policies and the opaqueness of the request-offer negotiating process. This paper attempts to assess what is on the table.
Gootiiz, Batshur, Mattoo, Aaditya
core  

The interface between the area of freedom, security and justice and the common foreign and security policy of the European Union: legal constraints to political objectives [PDF]

open access: yes, 2011
This paper argues that the objective of increased foreign policy coherence, as expressed in the Treaty of Lisbon and the Stockholm Programme of the European Union (EU), faces significant legal obstacles.
Van Elsuwege, Peter
core   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Robust inequality comparisons [PDF]

open access: yes
This paper is concerned with the problem of ranking Lorenz curves in situations where the Lorenz curves intersect and no unambiguous ranking can be attained without introducing weaker ranking criteria than first-degree Lorenz dominance. To deal with such
Magne Mogstad, Rolf Aaberge
core  

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