Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Superficial Medial Collateral Ligament Is the Primary Restraint to External Tibial Rotation Among Medial Knee Structures: A Robotic Biomechanical Study. [PDF]
Itagaki R +12 more
europepmc +1 more source
On the relationship between the number of solutions of congruence\n systems and the resultant of two polynomials [PDF]
Dmitry I. Khomovsky
openalex +1 more source
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
High-fidelity numerical framework for crashworthiness evaluation of passenger car body structures under full-frontal impact. [PDF]
Ponnusamy B.
europepmc +1 more source
Análise das aderências resultantes da fixação de telas cirúrgicas com selantes de fibrina e sutura: modelo experimental intraperitoneal [PDF]
Juliano Hermes Maeso Montes +6 more
openalex +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Relationship between ground reaction force and sacrum acceleration during 180° change of direction maneuvers in elite female basketball players. [PDF]
Ogata H +4 more
europepmc +1 more source

