Results 111 to 120 of about 15,148 (196)

The oncogenic CCDC6-RET fusion protein is a dual ATP- and ADP-dependent kinase. [PDF]

Nat Commun
Martín-Hurtado A, Contreras J, Sánchez-Wandelmer J, Zarzuela E, García F, Le Coq J, Boskovic J, Muñoz IG, Gago F, Muñoz J, Isasa M, Plaza-Menacho I.   +11 more
europepmc   +1 more source

Heat treatment combined with hybrid exercises retraining mitigates cellular markers of protein turnover after hindlimb suspension in male mice: A pilot study

Experimental Physiology, EarlyView.
Abstract Recent evidence suggests that heat treatment (HT) and resistance training can limit skeletal muscle mass loss during immobilization. However, the effects of repeated HT sessions combined with hybrid exercises (EX), which promote both endurance and resistance responses, on muscle protein turnover following hindlimb unloading (HU) remain ...
Tom Normand‐Gravier, Robert Solsona, Christelle Bertrand‐Gaday, Margot Issertine, Florence Sabatier, Flavie Arnould, Sébastien Racinais, Fabio Borrani, Henri Bernardi, Anthony M. J. Sanchez   +9 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion-positive cancer cells. [PDF]

Mol Oncol
Son J, Remsing Rix LL, Fang B, Welsh EA, Bremer NV, Foglizzo V, Roa P, Sigcha-Coello N, Liao Y, Haura EB, Drilon A, Koomen JM, Cocco E, Rix U.   +13 more
europepmc   +1 more source

Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights

The Journal of Physiology, EarlyView.
Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò, Miguel Martín‐Aragón Baudel, Charlotte E. R. Smith, Gonzalo Hernandez Hernandez, Donald M. Bers, Patrick M. Boyle, Dobromir Dobrev, Shanna Hamilton, Osama F. Harraz, Na Li, Thomas A. Longden, William E. Louch, Madeline Nieves‐Cintron, Matthew A. Nystoriak, Walter Lee Murfee, Przemysław B. Radwański, Swapnil K. Sonkusare, Manuel F. Navedo, Eleonora Grandi   +18 more
wiley   +1 more source

Targeted therapy combined with local consolidative surgery for oligometastatic stage IVA lung adenocarcinoma with CCDC6-RET fusion: a case report. [PDF]

Front Oncol
Gao F, Fan Y, Fan Q, Mei T, Khan MQ, Zhou A, Liu H, Dong J.   +7 more
europepmc   +1 more source

Four Decades of Research at the MADE Site and Beyond: Advancing the Understanding and Modeling of Solute Transport in Heterogeneous Media

Reviews of Geophysics, Volume 64, Issue 4, December 2026.
Abstract Spatial heterogeneity, manifested as strong variability in hydraulic conductivity (K) within geological formations, exerts a fundamental control on groundwater flow and solute transport. Because K can vary over multiple orders of magnitude in complex three‐dimensional patterns, predicting contaminant plume migration remains a long‐standing ...
Zhilin Guo, Maosheng Yin, Peiyao Dong, Yong Zhang, Kewei Chen, Graham Fogg, Brian Berkowitz, Marco Dentz, Chunmiao Zheng   +8 more
wiley   +1 more source

Durable response to selpercatinib in HOOK3-RET fusion positive, α-fetoprotein producing metastatic pancreatic ductal adenocarcinoma with intestinal-type differentiation. [PDF]

Oncol Lett
Sandhu HS, Natarajan A, Joshi S.
europepmc   +1 more source

Clinical Implementation and Oncological Relevance of Molecular Profiling in Brain Metastases Patients—A Multicenter Retrospective Cohort Study

International Journal of Cancer, Volume 159, Issue 10, Page 2562-2574, 15 November 2026.
While current guidelines recommend the analysis of established cancer driver genes in brain metastases, little is known about its real‐life implementation. This multicenter study revealed an upward trend in the profiling rates of surgically treated brain metastases over the past decade, with up to 60% of brain metastases samples undergoing analysis ...
Maria Nikolaeva, Jacopo Bellomo, Meltem Gönel, Vittorio Stumpo, Victor Egon Staartjes, Flavio Vasella, Kevin Akeret, André Sagerer, Anna Maria Zeitlberger, David Wasilewski, Christopher Krämer, Sven König, Julia Onken, Tareq Juratli, Alexander Köpp, Regina Reimann, Marcus Czabanka, Peter Vajkoczy, Ilker Y. Eyüpoglu, Oliver Bozinov, Michael Weller, Emilie Le Rhun, Luca Regli, Carlo Serra, Marian C. Neidert, Stefanos Voglis   +25 more
wiley   +1 more source

RET-fusion metastatic colon cancer responding to selpercatinib-a case report. [PDF]

Oxf Med Case Reports
Mullally WJ, Huo M, O'Byrne KJ.
europepmc   +1 more source

Utility of Fine Needle Aspiration Supernatant for Real‐Time PCR–Based Mutation Analysis in Non–Small Cell Lung Cancer

Diagnostic Cytopathology, Volume 54, Issue 11, Page 805-811, November 2026.
ABSTRACT Background The emergence of personalized therapy and molecular sequencing has significantly transformed the management of advanced non–small cell lung carcinoma (NSCLC). Supernatants obtained from fine needle aspiration (FNA) have been shown to be a reliable source of high‐quality nucleic acid for molecular testing.
Adeyinka Akinsanya, Riley Gorden, Madison Rector, Hamna Muhammad, Melissa Randolph, Matt Sperling, Kemin Xu, Sheila Segura, Omer Saeed, Tieying Hou   +9 more
wiley   +1 more source