Results 191 to 200 of about 939,495 (280)

The variability of giraffe skull morphology

open access: yesJournal of Anatomy, Volume 249, Issue 5, Page 1068-1086, November 2026.
What does giraffe skull shape tell us about their development and evolution? Abstract Giraffe (Giraffa spp.) are among the most unique and charismatic extant animals, largely due to their distinct morphology. The evolutionary and developmental origin of ossicones is a key factor in giraffid biology, yet other features building their characteristic head
Nikolaos Kargopoulos   +15 more
wiley   +1 more source

Beyond the Monolayer: Leveraging 3D Culture Systems to Decode Mechanisms of Drug Resistance and Therapeutic Vulnerabilities in Colorectal Cancer

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Two‐dimensional (2D) monolayer cultures remain the workhorse of colorectal cancer (CRC) research and high‐throughput screening (HTS), yet they poorly recapitulate tissue architecture, extracellular matrix (ECM) cues, metabolic gradients, and multicellular heterogeneity that govern drug response in vivo. Over the past decade, three‐dimensional (
Sarah J. Harmych, Bhuminder Singh
wiley   +1 more source

Response to Selpercatinib in a CCDC6-RET Lung Adenocarcinoma with an Acquired Novel RET p.L730_G731insL After Progression on Pralsetinib: A Case Report

open access: yesLung Cancer: Targets and Therapy
Chunyu Tian,1,* Yang Zou,1,* Jinxin Liu,1,* Jing Zhao,2 Simiao Tian,3 Ying Liu,1,4 Gang Wang1 1Department of Oncology III, Affiliated Zhongshan Hospital of Dalian Medical University, Dalian, Liaoning Province, People’s Republic of
Tian C   +6 more
doaj  

Selpercatinib-induced Acalculous Cholecystitis in an Elderly Patient with RET Fusion-positive Non-small Cell Lung Cancer. [PDF]

open access: yesIntern Med
Ichikawa T   +10 more
europepmc   +1 more source

Next‐Generation Sequencing‐Based Molecular Profiling and Management of Advanced Solid Tumors: A Real‐World Experience in a Community‐Based Academic Cancer Center

open access: yesCancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Advances in molecular and cell biology have led to a paradigm shift in cancer management. We implemented next‐generation sequencing (NGS) at our community‐based academic cancer center over a decade ago. We sought to optimize the use of genomics and understand its impact in identifying actionable genomic alterations to determine ...
Gayathri Moorthy   +19 more
wiley   +1 more source

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