Results 121 to 130 of about 2,837,491 (342)

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Dust retention in protoplanetary disks

open access: yes, 2009
Context: Protoplanetary disks are observed to remain dust-rich for up to several million years. Theoretical modeling, on the other hand, raises several questions.
Andrews   +29 more
core   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

open access: yesMolecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed   +8 more
wiley   +1 more source

Features of treatment of patients with complicated retention of the third molars at the inpatient stage [PDF]

open access: yesMedičnì Perspektivi, 2016
The aim of the study was to define frequency of infectious-inflammatory complications of the thirds molars retention and outcomes of surgical treatment in residents of Dnipro­petrovsk region on the basis of archiv materials. We surveyed 814 patients with
Gudaryan O.O.   +2 more
doaj  

The Use of Multi-Criteria Analysis for Identifying Areas Sensitive to Land Degradation and water Retention

open access: yesEkológia (Bratislava), 2018
The article presents a method of selecting critical areas (4th river basin) in terms of landscape degradation, with an emphasis on water retention, from a relatively larger unit (3rd river basin).
Bednář Marek, Šarapatka Bořivoj
doaj   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

open access: yesMolecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski   +19 more
wiley   +1 more source

Optimal Schedules in Multitask Motor Learning [PDF]

open access: yes, 2016
Although scheduling multiple tasks in motor learning to maximize long-term retention of performance is of great practical importance in sports training and motor rehabilitation after brain injury, it is unclear how to do so.
Kim, Sung Shin   +4 more
core   +1 more source

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