Results 91 to 100 of about 2,634,233 (294)

The Challenge of a Siberian Bluegrass (Poa) Phylogeny [PDF]

, 2010
In Siberia, the bluegrass genus (Poa) comprises 43 species and 61 subspecies in 12 sections. Diverse modes of speciation, including polyploidy and hybridization, have led to reticulate evolution and adaptive radiation.
Olonova, Marina V
core   +3 more sources

Re-evaluating homoploid reticulate evolution in the annual sunflowers

bioRxiv, 2022
Sunflowers of the genus Helianthus are models for hybridization research and contain three of the best studied examples of homoploid hybrid speciation. To understand the broader picture of hybridization within the annual sunflowers, we used whole genome ...
Gregory L. Owens, Kaichi Huang, M. Todesco, L. Rieseberg   +3 more
semanticscholar   +1 more source

Evidence for Widespread Reticulate Evolution within Human Duplicons [PDF]

The American Journal of Human Genetics, 2005
Approximately 5% of the human genome consists of segmental duplications that can cause genomic mutations and may play a role in gene innovation. Reticulate evolutionary processes, such as unequal crossing-over and gene conversion, are known to occur within specific duplicon families, but the broader contribution of these processes to the evolution of ...
JACKSON MS, OLIVER K, LOVELAND J, HUMPHRAY S, DUNHAM I, ROCCHI, Mariano, VIGGIANO, Luigi, PARK JP, HURLES ME, SANTIBANEZ KOREF M.   +9 more
openaire   +3 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The use of chloroplast genome sequences to solve phylogenetic incongruences in Polystachya Hook (Orchidaceae Juss) [PDF]

, 2018
Background: Current evidence suggests that for more robust estimates of species tree and divergence times, several unlinked genes are required. However, most phylogenetic trees for non-model organisms are based on single sequences or just a few regions ...
Acosta, Barros, Bräutigam, Capella-Gutiérrez, Carstens, Chang, Christenhusz, Cribb, Cronn, Dressler, Dressler, Eaton, Edwards, Freudenstein, Gustafsson, Górniak, Joly, Kamneva, Katoh, Kelchner, Kelchner, Kim, Kraenzlin, Lemmon, Lemmon, Li, Li, Luo, Mamanova, Marshall, McCormack, Michel, Mort, Mytnik-Ejsmont, Parks, Peraza-Flores, Pfeil, Rambaut, Rambaut, Ramírez, Ramírez, Ronquist, Rupp, Russell, Russell, Russell, Shaw, Shaw, Shaw, Small, Smith, Sousa, Steel, Stephens, Summerhayes, Summerhayes, Särkinen, Toor, Tsitrone, Van den Berg, Weitemier   +60 more
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Plant kleptomaniacs: geographical genetic patterns in the amphi-apomictic Rubus ser. Glandulosi (Rosaceae) reveal complex reticulate evolution of Eurasian brambles

bioRxiv
Rubus ser. Glandulosi represents a unique model of geographic parthenogenesis on a homoploid (4x) level. We employed double digest restriction-site associated DNA sequencing (ddRADseq) in 587 individuals of different Rubus taxa and modelling of suitable ...
M. Sochor, P. Šarhanová, M. Duchoslav, Michaela Konečná, Michal Hroneš, B. Trávníček   +5 more
semanticscholar   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Exploring phylogenetic hypotheses via Gibbs sampling on evolutionary networks

BMC Genomics, 2016
Background Phylogenetic networks are leaf-labeled graphs used to model and display complex evolutionary relationships that do not fit a single tree. There are two classes of phylogenetic networks: Data-display networks and evolutionary networks.
Yun Yu, Christopher Jermaine, Luay Nakhleh   +2 more
doaj   +1 more source

A bajocian (Middle jurassic) marine gastropod assemblage from the badamu formation, Central Iran [PDF]

, 2016
Nine species of gastropods are reported from the Bajocian (Middle Jurassic) part of the Badamu Formation of Central Iran. This is the first report of a gastropod assemblage of this age from the shelves of the Kimmerian Continent.
Binazadeh, Tayyeb, Ferrari, Silvia Mariel, Kaim, Andrzej   +2 more
core   +1 more source