Results 101 to 110 of about 2,634,233 (294)

Reticulate evolution helps explain apparent homoplasy in floral biology and pollination in baobabs (Adansonia; Bombacoideae; Malvaceae).

Systematic Biology, 2020
Baobabs (Adansonia) are a cohesive group of tropical trees with a disjunct distribution in Australia, Madagascar, and continental Africa, and diverse flowers associated with two pollination modes.
Nisa Karimi, C. Grover, J. Gallagher, J. Wendel, C. Ané, D. Baum   +5 more
semanticscholar   +1 more source

Reconstructing Reticulate Evolution in Species—Theory and Practice [PDF]

Journal of Computational Biology, 2005
We present new methods for reconstructing reticulate evolution of species due to events such as horizontal transfer or hybrid speciation; both methods are based upon extensions of Wayne Maddison's approach in his seminal 1997 paper. Our first method is a polynomial time algorithm for constructing phylogenetic networks from two gene trees contained ...
Luay, Nakhleh, Tandy, Warnow, C Randal, Linder, Katherine, St John   +3 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A model for hierarchical patterns under mechanical stresses

, 2009
We present a model for mechanically-induced pattern formation in growing biological tissues and discuss its application to the development of leaf venation networks.
Adda-Bedia, M., Corson, F., Henry, H.
core   +4 more sources

Trinets encode tree-child and level-2 phylogenetic networks [PDF]

, 2014
Phylogenetic networks generalize evolutionary trees, and are commonly used to represent evolutionary histories of species that undergo reticulate evolutionary processes such as hybridization, recombination and lateral gene transfer.
A Dress, AV Aho, C Scornavacca, D Morrison, DH Huson, G Cardona, G Cardona, G Cardona, G Cardona, G Cardona, G Cardona, G Jin, G Jin, J Byrka, J Fischer, J Jansson, KT Huber, Leo van Iersel, LJJ Iersel van, LJJ Iersel van, LJJ Iersel van, LJJ Iersel van, LJJ Iersel van, P Gambette, P Gambette, P Gambette, SJ Willson, Vincent Moulton   +27 more
core   +2 more sources

Topology of Reticulate Evolution

, 2016
The standard representation of evolutionary relationships is a bifurcating tree. However, many types of genetic exchange, collectively referred to as reticulate evolution, involve processes that cannot be modeled as trees. Increasing genomic data has pointed to the prevalence of reticulate processes, particularly in microorganisms, and underscored the ...
openaire   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Late-Pleistocene Syngenetic Permafrost in the CRREL Permafrost Tunnel, Fox, Alaska [PDF]

, 2008
contributing authors: Bjella, K.L., Bray, M.T., Collins, C.M., Douglas, T.A., Fortier, D., French, H.M., Kanevskiy, M.Z., Shur, Y.L.Late-Pleistocene syngenetic permafrost exposed in the walls and ceiling of the CRREL permafrost tunnel consists of ice-and
French, H.M., Kanevskiy, M.Z., Shur, Y.L.   +2 more
core  

Reticulate Evolution and Marine Organisms: The Final Frontier? [PDF]

International Journal of Molecular Sciences, 2009
The role that reticulate evolution (i.e., via lateral transfer, viral recombination and/or introgressive hybridization) has played in the origin and adaptation of individual taxa and even entire clades continues to be tested for all domains of life.
Arnold, Michael L., Fogarty, Nicole D.
openaire   +3 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source