Results 31 to 40 of about 1,415 (230)

Heat Stress Promotes Fibroblast‐Derived WNT5A Secretion Through m6A Modification to Activate Melanogenesis

open access: yesAdvanced Science, EarlyView.
Heat stress promotes WNT5A secretion from fibroblasts via METTL3/YTHDC1‐dependent m6A methylation. Subsequently, WNT5A binds to FZD10 on melanocytes, activating β‐catenin‐driven melanogenesis. ABSTRACT As the impact of global warming continues to intensify, the effects of heat stress on the skin are becoming increasingly evident.
Yuanyuan Wan   +13 more
wiley   +1 more source

The Network of Mystery: Unraveling Atypical Dermatopathia Pigmentosa Reticularis

open access: yesClinical Dermatology Review
Dermatopathia pigmentosa reticularis (DPR) is a rare ectodermal dysplasia characterized by generalized reticulate hyperpigmentation, nonscarring alopecia, and onychodystrophy, caused by autosomal dominant mutations in KRT14. Fewer than 25 cases have been
Spandana Devarahalli Krishnamurthy   +3 more
doaj   +1 more source

A Case of Laptop Computer-Induced Erythema Ab Igne

open access: yesHaseki Tıp Bülteni, 2014
Erythema ab igne, also known as toasted skin syndrome, is a skin reaction characterized by reticulate erythema, brown pigmentation, and telangiectasia. In some cases, epidermal atrophy and scaling are also identified.
Nurettin Özgür Doğan
doaj   +1 more source

Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity

open access: yesAdvanced Science, EarlyView.
Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang   +11 more
wiley   +1 more source

Gemcitabine, a rare cause of chemotherapy-related reticulate hyperpigmentation

open access: yesDermatology Reports
Reticulate pigmentary disorders can be classified into inherited or acquired and cutaneous drug- induced reticulate hyperpigmentation belongs to this last group.
Francesco Savoia   +4 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

open access: yesBMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang   +6 more
wiley   +1 more source

Progressive cribriform and zosteriform hyperpigmentation

open access: yesIndian Dermatology Online Journal, 2014
Here we report a case of a healthy 30-year-old male who presented to us with progressively increasing reticulate pigmented lesions following lines of Blaschko on the right side of abdomen and back.
Rameshwar M Gutte
doaj   +1 more source

Loss, persistence and reversal of phenotypic traits

open access: yesBiological Reviews, EarlyView.
ABSTRACT The irreversibility of complex trait loss has long been a tenet of evolutionary biology. However, this idea is increasingly at odds with the numerous documented exceptions across the Tree of Life. We synthesise this growing body of evidence across a diverse array of taxa and traits, exploring the evolutionary conditions that enable ...
Giobbe Forni   +4 more
wiley   +1 more source

A Novel Locus for Ectodermal Dysplasia of Hair, Nail and Skin Pigmentation Anomalies Maps to Chromosome 18p11.32-p11.31. [PDF]

open access: yesPLoS ONE, 2015
Ectodermal dysplasias (EDs) are a large heterogeneous group of inherited disorders exhibiting abnormalities in ectodermally derived appendages such as hair, nails, teeth and sweat glands.
Rabia Habib   +6 more
doaj   +1 more source

Case report: A novel mutation in RTEL1 gene in dyskeratosis congenita

open access: yesFrontiers in Oncology, 2023
Dyskeratosis congenita (DKC), also known as Zinsser–Cole–Engman syndrome, is a telomeropathy typically presenting as a triad of leukoplakia, nail dystrophy, and reticular hyperpigmentation.
Haider Nisar   +5 more
doaj   +1 more source

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