Results 131 to 140 of about 558,236 (245)

Obesity‐Related Inflammation Masks Iron Deficiency in US Women

American Journal of Hematology, Volume 101, Issue 12, Page 3043-3046, December 2026.
Sixtus Aguree, Sai Chakrri Tadikonda
wiley   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities

American Journal of Hematology, Volume 101, Issue 11, Page 2799-2811, November 2026.
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Halima Bello‐Manga, Shehu Umar Abdullahi, Hoda Hassab, Biobele Brown, Videlis Nduba, Jessie Githanga, Adeseye Michael Akinsete, Amal El‐Beshlawy, Diana Hanna, Catherine Segbefia, Iheanyi Okpala, Azza Tantawy, Bernhards Ogutu, Venée N. Tubman, Vivian Paintsil, Yasser Wali, Mohammed Essa, Paul Telfer, Sandy Dixon, Anne Hickman, Jennifer F. Doss, Mark W. Davis, Jeremy Rupon, Fenella J. Kirkham, R. Clark Brown, on behalf of the HOPE Kids 2 Investigators, Amal El‐Beshlawy, Mohamed Badr, Diana Hanna*, Hoda Hassab, Azza Tantawy, Vivian Paintsil, Catherine Segbefia, Raffaella Colombatti, Daniela Cuzzubbo, Silverio Perrotta, Jessie Githanga, Videlis Nduba, Bernhards Ogutu, Shehu Umar Abdullahi, Adeseye Michael Akinsete, Halima Bello‐Manga, Biobele Brown, Iheanyi Okpala, Yasser Wali, Mohammed Essa, Banu Kaya, Paul Telfer, Ofelia Alvarez, Natasha Archer, Shayla Bergmann, R Clark Brown, Andrew Campbell, Carlton Dampier*, Richard Hurwitz, Erin Jackson, Janet Kwiatkowski, Melissa M. McNaull*, Venée N. Tubman   +58 more
wiley   +1 more source

Time to first event and cumulative mean frequency of events.

, 2013
A. Kaplan Meier curve showing the cumulative proportion of events by patient groups. The groups were divided by absolute reticulocyte count based on the ROC curve seen in Figure 3 [absolute reticulocyte count >205 K/uL (solid line, n = 19, 0.84, 95% CI 0.
Naomi L. C. Luban (443101), Y. Terry Lee (431549), Colleen Byrnes (431551), Elizabeth C. Wright (443100), Alan N. Schechter (99551), Emily Riehm Meier (443099), Jeffery L. Miller (431556)   +6 more
core   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2378-2389, November 2026.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Leveraging absolute reticulocyte count and reticulocyte percentage to differentiate pure red cell aplasia from aplastic anemia

Therapeutic Advances in Hematology
Background Overlapping disease features, secondary etiologies, and patient comorbidities contribute to diagnostic ambiguity between pure red cell aplasia (PRCA) and aplastic anemia (AA).
Jimmy Lee, Isa Faghihi, Mutlu Mete, Hussein Awada, Ana Plesca, Serhan Unlu, Valeria Visconte, Carmelo Gurnari, Jaroslaw P. Maciejewski, Taha Bat   +9 more
doaj   +1 more source

SLE Complicated With AIHA and Parvovirus B19 Infection Secondary to PRCA: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
We report the diagnosis and treatment process of a female with SLE and AIHA infected with parvovirus B19 and secondary PRCA. Interestingly, there was no significant increase in hemoglobin after IVIG treatment for more than 50 days; however, the addition of foscarnet showed good efficacy.
Mingquan Xing, Siqi Zhang, Yanrong Zhang, Xiaoxing Sun, Hongfeng Ge   +4 more
wiley   +1 more source

GATA2 Deficiency Presenting With a WHIM‐Like Phenotype and Subsequent Development of Monosomy 7‐Associated Myelodysplastic Syndrome in an Adolescent Female: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT We report an 18‐year‐old female with GATA2 deficiency presenting with a WHIM‐like phenotype, including pancytopenia, monocytopenia, CD19+ B‐cell depletion, sensorineural hearing loss, and cutaneous warts. Subsequent cytogenetic evaluation revealed monosomy 7 and 7q22 deletion, with bone marrow progression to MDS.
Aziz Eghbali, Meshkat Poortavakol, Hamideh Sadat Mirmohammadi   +2 more
wiley   +1 more source

Computational Prediction of Immunogenic Epitopes and Protein Structures of Heat Shock Protein 90 in Toxoplasma gondii

Immunity, Inflammation and Disease, Volume 14, Issue 11, November 2026.
ABSTRACT Introduction Toxoplasma gondii (T. gondii) is an obligate intracellular protozoan parasite that poses a significant threat to both human and animal health worldwide. Despite extensive research efforts, no effective vaccine is currently available for human use.
Amirhossein Abedi, Ali Dalir Ghaffari, Sobhan Dehghanpour, Mohammad Fekrikia   +3 more
wiley   +1 more source

Safety, Pharmacokinetics, and Efficacy Study of Porcine and Rabbit Antithymocyte Globulin in the Treatment of Patients With Severe Aplastic Anemia: A Multicenter, Prospective, Randomized, Open‐Label Clinical Trial

MedComm, Volume 7, Issue 11, November 2026.
This prospective trial compared porcine‐ATG and rabbit‐ATG for severe aplastic anemia. Both agents peaked on Day 5, with faster clearance for rabbit‐ATG. Porcine‐ATG induced an early stable neutrophil rise, whereas rabbit‐ATG caused an initial neutrophil drop.
Yawen Zhang, Yingying Zhang, Yuemin Gong, Yu Sun, Guangsheng He   +4 more
wiley   +1 more source

Computational Optimisation of EtAMA1 Reveals Its Potential as a Vaccine Candidate Against Eimeria tenella

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Eimeria tenella is one of the main causes of coccidiosis in poultry, with increasing drug resistance highlighting the need for alternate control strategies. This study identified Eimeria tenella AMA1 (EtAMA1) as a promising vaccine candidate through structural analysis, epitope prediction, immune simulation, and molecular docking, which demonstrated ...
Nooran Mahomed Rafeer, Victoria Teniola Adeleke, Matthew Adekunle Adeleke   +2 more
wiley   +1 more source