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Tropism of Plasmodium malariae for young red blood cells and the bone marrow [PDF]

Emerging Microbes and Infections
Fundamental aspects of the biology of the third most prevalent human malaria species Plasmodium malariae, including the basis for its capacity to establish chronic, low-density infections associated with debilitating quartan fevers, remain poorly ...
Barbara Mouyama, Vivienne Fey, Dorenda J.A. Schoorl, Malika Serra-Hassoun, Fidelis Ambinintsoa, Barclaye Ngossanga, Leticia Hartmann, Ayola A. Adegnika, Artur Scherf, Mario Recker, Rolf Fendel, Steffen Borrmann, Sylvie Garcia   +12 more
doaj   +2 more sources

Hematopoietic stem/progenitor cell sources to generate reticulocytes for Plasmodium vivax culture. [PDF]

PLoS ONE, 2014
The predilection of Plasmodium vivax (P. vivax) for reticulocytes is a major obstacle for its establishment in a long-term culture system, as this requires a continuous supply of large quantities of reticulocytes, representing only 1-2% of circulating ...
Florian Noulin, Javed Karim Manesia, Anna Rosanas-Urgell, Annette Erhart, Céline Borlon, Jan Van Den Abbeele, Umberto d'Alessandro, Catherine M Verfaillie   +7 more
doaj   +3 more sources

Significant Biochemical, Biophysical and Metabolic Diversity in Circulating Human Cord Blood Reticulocytes

PLoS ONE, 2013
BackgroundThe transition from enucleated reticulocytes to mature normocytes is marked by substantial remodeling of the erythrocytic cytoplasm and membrane.
Yves Colin, Cindy Chu, Benoit Malleret
exaly   +2 more sources

The protective effect of the spleen in sickle cell patients. A comparative study between patients with asplenia/hyposplenism and hypersplenism

Frontiers in Physiology, 2022
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterized by chronic hemolytic anemia, vaso-occlusive events leading to tissue ischemia, and progressive organ failure.
Sari Peretz, Sari Peretz, Leonid Livshits, Leonid Livshits, Etheresia Pretorius, Asya Makhro, Anna Bogdanova, Anna Bogdanova, Max Gassmann, Ariel Koren, Carina Levin, Carina Levin   +11 more
doaj   +1 more source

A Proposed Concept for Defective Mitophagy Leading to Late Stage Ineffective Erythropoiesis in Pyruvate Kinase Deficiency

Frontiers in Physiology, 2021
Pyruvate kinase deficiency (PKD) is a rare congenital hemolytic anemia caused by mutations in the PKLR gene. Here, we review pathophysiological aspects of PKD, focusing on the interplay between pyruvate kinase (PK)-activity and reticulocyte maturation in
Annelies Johanna van Vuren, Eduard Johannes van Beers, Richard van Wijk   +2 more
doaj   +1 more source

Clinical utility of immature reticulocyte fraction for identifying early red blood cell regeneration in anemic dogs

Journal of Veterinary Internal Medicine, 2023
Background Evaluating regeneration is essential for the classification and differential diagnosis of anemia in dogs. Early detection of regeneration is challenging in anemic dogs. Objectives This study assessed the value of immature reticulocyte fraction
Jae‐Ha Jung, Yeseul Yang, Dansong Seo, Soyeon Cho, Goeun Choi, Yongbaek Kim   +5 more
doaj   +1 more source

A brief overview of BNIP3L/NIX receptor‐mediated mitophagy

FEBS Open Bio, 2021
Mitophagy is a form of autophagy specialized to selectively remove mitochondria. Although the PINK1/Parkin pathway is the best described mitophagy of damaged mitochondria, receptor/mediated mitophagy seems to have a pivotal role in cellular development ...
Mija Marinković, Ivana Novak
doaj   +1 more source

Potential value of differential expression of CDC42 gene in adult and umbilical cord blood reticulocytes

Zhongguo shuxue zazhi, 2023
Objective To explore critical regulatory genes in the hemoglobin switch process by analyzing transcriptomic data from the GSE6236, GSE17639 and GSE35102 datasets.
Jinchao WANG, Genhao ZHANG
doaj   +1 more source

Home Sweet Home: Plasmodium vivax-Infected Reticulocytes—The Younger the Better?

Frontiers in Cellular and Infection Microbiology, 2021
After a century of constant failure to produce an in vitro culture of the most widespread human malaria parasite Plasmodium vivax, recent advances have highlighted the difficulties to provide this parasite with a healthy host cell to invade, develop, and
Richard Thomson-Luque, José M. Bautista
doaj   +1 more source

Cryopreserved reticulocytes derived from hematopoietic stem cells can be invaded by cryopreserved Plasmodium vivax isolates. [PDF]

PLoS ONE, 2012
The development of a system for the continuous culture of Plasmodium vivax in vitro would benefit from the use of reticulocytes derived from differentiated hematopoietic stem cells (HCS).
Florian Noulin, Céline Borlon, Peter van den Eede, Luc Boel, Catherine M Verfaillie, Umberto D'Alessandro, Annette Erhart   +6 more
doaj   +1 more source