Results 11 to 20 of about 1,434 (146)
Hard-To-Treat Idiopathic Refractory Autoimmune Haemolytic Anaemia with Reticulocytopenia [PDF]
Autoimmune haemolytic anaemia (AIHA) is an uncommon condition characterized by increased destruction of erythrocytes associated with reticulocytosis in the great majority of cases.
Marcelo Aveiro +4 more
doaj +2 more sources
Eculizumab as a Treatment for Hyper-Haemolytic and Aplastic Crisis in Sickle Cell Disease [PDF]
Background: Patients with sickle cell disease can experience various crises including sequestration crisis, haemolytic crisis and aplastic crisis. Due to alloantibody formation, transfusion alloantibodies can cause a haemolytic crisis. Treatment involves
Ishan Patel +7 more
doaj +2 more sources
Monoclonal gammopathy‐associated pure red cell aplasia (MG‐PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a ...
Christian Sebastian Michel +8 more
doaj +3 more sources
Aggressive Systemic Mastocytosis in Association with Pure Red Cell Aplasia
Aggressive systemic mastocytosis (ASM) is characterized by mast cell accumulation in systemic organs. Though ASM may be associated with other hematological disorders, the association with pure red cell aplasia (PRCA) is rare and has not been reported ...
Dhauna Karam +3 more
doaj +2 more sources
We present a four-month-old girl with severe hemolytic anemia and reticulocytopenia. This case is the youngest with hemolytic anemia encountered in our hospital. Findings of autoimmune hemolytic anemia were preceded by diphtheria-pertussis-tetanus
L Olcay, A Düzova, F Gümrük
doaj +1 more source
Transcription Factors GATA1/2 in Hematological Disorders [PDF]
ABSTRACT Background GATA1 and GATA2 are zinc‐finger transcription factors essential for normal hematopoiesis. As genetic testing becomes more widely integrated into clinical practice, GATA1/2‐related disorders are increasingly recognized, making it important for clinicians to understand their diagnosis and management.
Matthew Karr +2 more
wiley +2 more sources
Decoding immune‐driven erythroid failure in pure red cell aplasia [PDF]
Pure red cell aplasia (PRCA) is increasingly recognised as a T‐cell‐mediated bone marrow failure syndrome, yet its immunogenetic drivers remain poorly defined. In their paper, Yamashita et al. integrate human leucocyte antigen (HLA) typing, T‐cell receptor repertoire analysis and mutational profiling to reveal enriched HLA alleles, signal transducer ...
Federico Spataro +2 more
wiley +2 more sources
Use of IV immunoglobulin to treat steroid resistant, immune checkpoint inhibitor‐induced pure red cell aplasia: A case report [PDF]
Pure red cell aplasia (PRCA) is characterised by normocytic normochromic anaemia, reticulocytopenia and reduced erythroid precursors in bone marrow. PRCA as an immune‐related adverse event secondary to immune checkpoint inhibitor (ICI) therapy is rare ...
Sam Sherratt‐Mayhew +1 more
doaj +2 more sources
A meta‐analysis of toxicities related to hydroxycarbamide dosing strategies
Due to fear of short‐term toxicities, there is nonconsensus of hydroxycarbamide dosing strategy (escalated vs fixed‐dosing methods), which contributes to its suboptimal use.
Joacy G. Mathias +9 more
doaj +2 more sources
Pure red cell aplasia in chronic lymphocytic leukemia: Case report and review of literature
Despite being immune deficient, chronic lymphocytic leukemia (CLL) patients have an increased incidence of autoimmune cytopenias secondary to autoantibody formation.
Hassanain H Al-Charrakh +1 more
doaj +2 more sources

