Results 41 to 50 of about 1,235 (149)

Pure red cell aplasia in chronic lymphocytic leukemia: Case report and review of literature

Iraqi Journal of Hematology, 2016
Despite being immune deficient, chronic lymphocytic leukemia (CLL) patients have an increased incidence of autoimmune cytopenias secondary to autoantibody formation.
Hassanain H Al-Charrakh, Liqaa M Al-Shareefy   +1 more
doaj   +1 more source

Effective treatment of refractory acquired pure red blood cell aplasia with eltrombopag and sirolimus: a case report

Therapeutic Advances in Hematology, 2020
Acquired pure red cell aplasia (aPRCA) is a kind of anemia characterized by severe reticulocytopenia and reduced bone marrow erythroblastic cells. For patients who are refractory to the first-line therapy (cyclosporin A with/without glucocorticoids ...
Yuzhou Huang, Xianyong Jiang, Bing Han
doaj   +1 more source

Hemophagocytic Lymphohistiocytosis Triggered by Legionella pneumophila and SARS‐CoV‐2 Infection in GATA2 Deficiency

Clinical Case Reports, Volume 14, Issue 5, May 2026.
ABSTRACT Germline GATA2 deficiency predisposes to bone marrow failure, myeloid neoplasia, and immune dysregulation. The syndrome is often complicated by infection with intracellular pathogens and viruses, autoimmunity, and inflammation. Hemophagocytic lymphohistiocytosis (HLH) is a rare occurrence that can present further management challenges.
Harry Wilson, Nuno Borges, Matthew Collin, Callum Wright   +3 more
wiley   +1 more source

Immunological features of acquired pure red cell aplasia: Specific human leucocyte antigen alleles, signal transducer and activator of transcription 3 mutations and a unique T‐cell receptor beta motif

British Journal of Haematology, Volume 208, Issue 5, Page 1797-1805, May 2026.
Summary T‐cell abnormalities have been implicated in the pathogenesis of acquired pure red cell aplasia (PRCA), particularly in its major subtypes such as idiopathic PRCA, thymoma‐associated PRCA and large granular lymphocytic leukaemia (LGLL)–associated PRCA, and the precise details remain unclear.
Naruaki Yamashita, Toru Kawakami, Shuji Matsuzawa, Shotaro Miyairi, Masae Maruyama, Fumihiro Kawakami, Shunsuke Kojima, Ryu Yanagisawa, Yumiko Higuchi, Hideki Makishima, Hideyuki Nakazawa, Fumihiro Ishida   +11 more
wiley   +1 more source

Paroxysmal Nocturnal Haemoglobinuria‐Associated Acute Cutaneous Thrombosis and Haemolysis in the Setting of Parvovirus B19 and Varicella Zoster Virus Infection

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT A 28‐year‐old male with paroxysmal nocturnal haemoglobinuria (PNH) presented with headache, nasal bridge discomfort and haemoglobinuria. He developed a macular‐papular rash which rapidly progressed into purpura, necrosis and peri‐orbital oedema. Investigations demonstrated severe haemolytic anaemia and acute parvovirus B19 infection.
Louise J. Potter, Roochi Trikha, Shreyans Gandhi, Joanne Large, Tanya N. Basu, Jeanne Boissiere, Hannah Devine, Taku Sugai, Aushna Rasool, Austin Kulasekararaj   +9 more
wiley   +1 more source

Somatic Mutations in Acquired Pure Red Cell Aplasia: Incidence and Implications

American Journal of Hematology, Volume 101, Issue 7, Page 1554-1555, July 2026.
Robert T. Means Jr
wiley   +1 more source

DNA Methylation Episignature as a Novel Diagnostic Tool for Diamond‐Blackfan Anemia Syndrome

American Journal of Hematology, Volume 101, Issue 2, Page 228-241, February 2026.
Diamond‐Blackfan Anemia Syndrome (DBAS) is a congenital bone marrow failure disorder characterized by defective erythropoiesis and a spectrum of congenital anomalies, including craniofacial malformations, limb abnormalities, and cardiac and renal defects.
Paola Quarello, Karim Karimi, Slavica Trajkova, Emanuela Garelli, Mehdi Samadieh, Emanuela Iovino, Tommaso Pippucci, Giovanni Papagni, Sandra Dalfonso, Lucia Corrado, Serena Rizzo, Adriana Carando, Jennifer Kerkhof, Jessica Rzasa, Haley McConkey, Michael Levy, Marco Zecca, Francesca Fioredda, Angelica Barone, Simone Cesaro, Maria Gabelli, Francesca Torchio, Giulia Zucchetti, Maria Elena Cantarini, Paola Corti, Ugo Ramenghi, Franco Locatelli, Franca Fagioli, Bekim Sadikovic, Alfredo Brusco   +29 more
wiley   +1 more source

Effective treatment of refractory monoclonal gammopathy‐associated pure red cell aplasia with isatuximab, pomalidomide and dexamethasone

eJHaem
Monoclonal gammopathy‐associated pure red cell aplasia (MG‐PRCA) is characterized by the absence or pronounced hypoplasia of erythroid precursors in the bone marrow, causing reticulocytopenia and a normocytic, normochromic anaemia in a patient with a ...
Christian Sebastian Michel, Eva Marie Fehr, Hildegard Nolte, Joachim Beck, Andreas Kreft, Katharina Theresa Rauschkolb‐Olk, Bjoern Jacobi, Matthias Theobald, Markus Munder   +8 more
doaj   +1 more source

Tocilizumab provides a potential therapeutic option for the management of hyperhaemolysis syndrome in sickle cell disease: A case series and brief narrative overview of the literature

Transfusion Medicine, Volume 36, Issue 1, Page 66-71, February 2026.
Abstract Background and Objectives Hyperhaemolysis syndrome is a life‐threatening complication of transfusion, potentially triggered by macrophage activation, with limited treatment options. Tocilizumab, an anti‐IL6 monoclonal antibody, has mechanistic rationale for use and has been shown to be effective in a small number of cases.
S. Wolf, B. Singh, A. Zaidi, P. Greaves, F. Oyesanya, S. Bennett, B. Kaya, F. Barroso, P. Telfer   +8 more
wiley   +1 more source

Preservative Monitoring of a Greek Woman with Hydrops Fetalis due to Parvovirus B19 Infection

Case Reports in Obstetrics and Gynecology, 2017
Primate erythroparvovirus 1 (parvovirus B19) is a member of the Erythrovirus genus of the Parvoviridae family and it is one of the few members of the family known to be pathogenic in human.
Zacharias Fasoulakis, Panagiotis Antsaklis, Emmanuel N. Kontomanolis   +2 more
doaj   +1 more source