Results 161 to 170 of about 315,719 (318)
Therapeutic Gene Editing of APOE4 in Sporadic Alzheimer's Disease via Prime Editor 7
Advanced Science, EarlyView.Prime Editor 7‐mediated conversion of APOE4 to APOE3 alleviates Alzheimer's disease‐associated pathology in AD mouse models and patient‐derived neurons and improves cognitive performance in vivo, supporting therapeutic genome editing as a promising strategy for APOE4‐associated neurodegeneration.
Yunkyung Kim +16 more
wiley +1 more source
Untangling Inositol (Pyro)Phosphate Biology Through Emerging Technologies
Advanced Science, EarlyView.Inositol (pyro)phosphates represent a vital class of intracellular messengers that govern multiple biological processes. The last decade has experienced a surge of interest in the functions of this class of signaling molecules, primarily due to the introduction of several innovative analytical technologies.
Adolfo Saiardi +5 more
wiley +1 more source
Advanced Science, EarlyView.Pasta is a transcriptomic aging clock built on an age‐shift learning framework and trained on 17 000 samples across 21 datasets. It accurately predicts relative biological age across tissues, platforms, and species, captures stemness‐to‐senescence transitions, and identifies age‐modulatory perturbations.
Jérôme Salignon +6 more
wiley +1 more source
Laser photocoagulation improves the transduction efficiency of lentivirus vectors injected intravitreally. [PDF]
Int J OphthalmolJiao J, Xu YJ, Li XD, Hua W, Jiang YR.
europepmc +1 more source
Advanced Science, EarlyView.A cationic poly(disulfide)‐drug nanoplatform (LA/DexP) was developed to treat experimental autoimmune uveitis (EAU). With potent blood‐retinal barrier penetrability, LA/DexP releases DSP in response to high ROS and scavenges cfDNA to inhibit the cGAS‐STING signaling pathway.
Yuelan Wu +12 more
wiley +1 more source
Semi‐Transparent Organic Photodiodes with Near‐Infrared Detection Fabricated by Inkjet Printing
Advanced Electronic Materials, EarlyView.This work shows the inkjet printing of semi‐transparent and opaque organic photodiodes that enable light detection in the near‐infrared regime. Their transparency and high detection speed make them ideal for applications in soft robotics, wearable devices, and light communication systems.
Luis Arturo Ruiz‐Preciado +3 more
wiley +1 more source
Eye Morphology, Foveal Structure and Photoreceptor Composition in Both Foveae of Common Kestrel (<i>Falco tinnunculus</i> Linnaeus, 1758). [PDF]
Biology (Basel)Cobo R +4 more
europepmc +1 more source
Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents
Advanced Intelligent Discovery, EarlyView.This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer +3 more
wiley +1 more source
Clinical OphthalmologySomnath Chakraborty,1 Jay U Sheth,2 Santanu Ganguly,1 Rahul Reddy1 1Department of Retina Services, Retina Institute of Bengal, Siliguri, India; 2Department of Retina Services, Shantilal Shanghvi Eye Institute, Mumbai, IndiaCorrespondence: Somnath ...
Chakraborty S +3 more
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