Results 41 to 50 of about 573,457 (326)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Faricimab for treatment-resistant choroidal neovascularization (CNV) in neovascular age-related macular degeneration (nAMD): seven-months results using artificial intelligence and OCTA

International Journal of Retina and Vitreous
Background To analyze the therapeutic response to faricimab 6 mg/0.05 ml in eyes with neovascular AMD (nAMD) with refractory intra- and/or subretinal fluid due to choroidal neovascularization (CNV), previously unresponsive to 4 mg monthly aflibercept and
Anna Heinke, Alexandra Warter, Ines D. Nagel, Akshay Agnihotri, Nehal Nailesh Mehta, Carlo Miguel B. Galang, Daniel N. Deussen, Dirk-Uwe G. Bartsch, Lingyun Cheng, Henry A. Ferreyra, William R. Freeman   +10 more
doaj   +1 more source

Latitude and longitude vertical disparities [PDF]

, 2009
The literature on vertical disparity is complicated by the fact that several different definitions of the term “vertical disparity” are in common use, often without a clear statement about which is intended or a widespread appreciation of the properties ...
Glennerster, Andrew, Phillipson, Graeme P., Read, Jenny C. A.   +2 more
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Retinal tear formation after whole-body vibration training exercise

BMC Ophthalmology, 2020
Background The purpose of this report is to describe the occurrence of a retinal tear, pre-retinal and vitreous hemorrhages after completing a session of whole-body vibration training.
John Maggiano, Mei-Chuan Margret Yu, Sanford Chen, Timothy You, Rajiv Rathod   +4 more
doaj   +1 more source

Distribution of melanopsin positive neurons in pigmented and albino mice: evidence for melanopsin interneurons in the mouse retina. [PDF]

, 2014
Here we have studied the population of intrinsically photosensitive retinal ganglion cells (ipRGCs) in adult pigmented and albino mice. Our data show that although pigmented (C57Bl/6) and albino (Swiss) mice have a similar total number of ipRGCs, their ...
Agudo-Barriuso, M, Galindo-Romero, C, García-Ayuso, D, Jiménez-López, M, Ortín-Martínez, A, Valiente-Soriano, FJ, Vidal-Sanz, M, Villegas-Pérez, MP, Vugler, AA   +8 more
core  

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Effect of manual OCTA segmentation correction to improve image quality and visibility of choroidal neovascularization in AMD

Scientific Reports
In this retrospective case series on neovascular age-related macular degeneration (nAMD), we aimed to improve Choroidal Neovascularization (CNV) visualization in Optical Coherence Tomography Angiography (OCTA) scans by addressing segmentation errors. Out
Daniel N. Deussen, Anna Heinke, Wyatt Elsner, Carlo Miguel B. Galang, Fritz Gerald P. Kalaw, Alexandra Warter, Dirk-Uwe Bartsch, Lingyun Cheng, William R. Freeman   +8 more
doaj   +1 more source

An Approach to Distance Estimation with Stereo Vision Using Address-Event-Representation [PDF]

, 2011
Image processing in digital computer systems usually considers the visual information as a sequence of frames. These frames are from cameras that capture reality for a short period of time.
Cerezuela Escudero, Elena, Domínguez Morales, Manuel Jesús, Jiménez Fernández, Ángel Francisco, Jiménez Moreno, Gabriel, Linares Barranco, Alejandro, López-Torres, Manuel Ramón., Morgado Estévez, Arturo, Paz Vicente, Rafael   +7 more
core   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source