Results 41 to 50 of about 409,228 (346)

Spectral domain OCT features in type 2 macular telangiectasia (type 2 MacTel): its relevance with clinical staging and visual acuity

International Journal of Retina and Vitreous, 2022
Background To report spectral domain optical coherence tomography (SDOCT) imaging findings in type 2 macular telangiectasia (MacTel) and correlate them with clinical stages and visual acuity.
Ramesh Venkatesh, Nikitha Gurram Reddy, Pranjal Mishra, Sameeksha Agrawal, Deepashri Mutalik, Naresh Kumar Yadav, Jay Chhablani   +6 more
doaj   +1 more source

BCS1L‐Associated Disease: 5′‐UTR Variant Shifts the Phenotype Towards Axonal Neuropathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives To investigate the consequences of a pathogenic missense variant (c.838C>T; p.L280F) and a 5′‐UTR regulatory variant (c.‐122G>T) in BCS1L on disease pathogenesis and to understand how regulatory variants influence disease severity and clinical presentation.
Rotem Orbach, Nunziata Maio, Russell J. Butterfield, A. Reghan Foley, Sarah Silverstein, Yan Li, Katherine Chao, Tanya J. Lehky, Abigail Potticary, Tracey A. Rouault, Sandra Donkervoort, Carsten G. Bönnemann   +11 more
wiley   +1 more source

Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina

Scientific Reports, 2016
The recent paradigm shift that microglia are yolk sac-derived, not hematopoietic-derived, is reshaping our knowledge about the isolated role of microglia in CNS diseases, including degenerative conditions of the retina.
Emily G. O’Koren, R. Mathew, D. Saban
semanticscholar   +1 more source

Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The characteristics and utility of composite progression independent of relapse activity (cPIRA; worsening on the Expanded Disability Status Scale [EDSS], or 9‐Hole Peg Test, or Timed 25‐Foot Walk Test) were evaluated as an endpoint in relapsing multiple sclerosis (RMS) trials using the ENSEMBLE (NCT03085810) and pooled OPERA I/II ...
Ludwig Kappos, Sean Yiu, Jason Reucassel, Jiwon Oh, Cristina Granziera, Joep Killestein, Robert A. Bermel, Claude Berge, Agne Kazlauskaite, Hans‐Martin Schneble, Frank Dahlke, Bruce A. C. Cree   +11 more
wiley   +1 more source

DETACHMENT OF RETINA. [PDF]

The Lancet, 1878
n ...
openaire   +2 more sources

Requirement for Microglia for the Maintenance of Synaptic Function and Integrity in the Mature Retina

Journal of Neuroscience, 2016
Microglia, the principal resident immune cell of the CNS, exert significant influence on neurons during development and in pathological situations. However, if and how microglia contribute to normal neuronal function in the mature uninjured CNS is not ...
Xu Wang, Lian Zhao, Jun Zhang, R. Fariss, Wenxin Ma, F. Kretschmer, Minhua H. Wang, H. Qian, T. Badea, J. Diamond, W. Gan, J. Roger, W. Wong   +12 more
semanticscholar   +1 more source

Comparative Effect of Standard Versus Extended Interval Dosing of Rituximab or Ocrelizumab in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aimed to investigate the comparative effectiveness of standard versus personalized extended interval dosing of anti‐CD20 therapy on clinical and sub‐clinical outcomes in multiple sclerosis. Methods Clinical information was collected prospectively on Research Electronic Data Capture.
Nabil K. El Ayoubi, Fares Fahd, Hani Tamim, Salem Hannoun, Mark Bal, Elham El‐Hallak, Samia J. Khoury   +6 more
wiley   +1 more source

Effect of manual OCTA segmentation correction to improve image quality and visibility of choroidal neovascularization in AMD

Scientific Reports
In this retrospective case series on neovascular age-related macular degeneration (nAMD), we aimed to improve Choroidal Neovascularization (CNV) visualization in Optical Coherence Tomography Angiography (OCTA) scans by addressing segmentation errors. Out
Daniel N. Deussen, Anna Heinke, Wyatt Elsner, Carlo Miguel B. Galang, Fritz Gerald P. Kalaw, Alexandra Warter, Dirk-Uwe Bartsch, Lingyun Cheng, William R. Freeman   +8 more
doaj   +1 more source

ATROPHY OF THE RETINA. [PDF]

JAMA: The Journal of the American Medical Association, 1901
It may be sometimes quite impossible to discover the cause of disease, and it is not always easy to determine whether a lesion is dependent upon some other morbid process, or of primary origin. I have hesitated to believe it possible for atrophy of the retina to come on as a primary condition, without any discoverable preceding inflammation, or even ...
openaire   +3 more sources

Microphysiological Glomerular Filtration Barriers: Current Insights, Innovations, and Future Applications

Advanced Biology, EarlyView.
The glomerular filtration barrier (GFB) is the first step of blood filtration by the kidneys. The concerning increase of kidney diseases makes the development of new models essential. In this context, microphysiological glomerular filtration barriers focus on closely reproducing the physiological architecture of the in vivo GFB: podocytes, glomerular ...
Manon Miran, Kieu Ngo, David Buob, Hanna Debiec, Pierre Ronco, Guillaume Perry   +5 more
wiley   +1 more source