Results 111 to 120 of about 211,361 (268)

Single‐Cell Annotation and Localization via Integrating Spatial Transcriptomics Maps the Mouse Ocular Atlas and RAO Dynamics

open access: yesAdvanced Science, EarlyView.
We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du   +11 more
wiley   +1 more source

Long-term gene therapy causes transgene-specific changes in the morphology of regenerating retinal ganglion cells

open access: yes, 2012
Recombinant adeno-associated viral (rAAV) vectors can be used to introduce neurotrophic genes into injured CNS neurons, promoting survival and axonal regeneration.
Rodger Jennifer   +14 more
core   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

open access: yesAdvanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang   +4 more
wiley   +1 more source

Chronic Disease Monitoring Using Advanced Compliant Materials for Bioelectronics

open access: yesAdvanced Electronic Materials, EarlyView.
Compliant bioelectronic systems enable continuous monitoring of chronic disease through soft, stretchable materials and tissue‐conformal designs that support stable electrophysiological, mechanical, and biochemical sensing. Integration of diverse sensing modalities with thoughtful material selection, device architectures, and advanced fabrication ...
Han Kim   +7 more
wiley   +1 more source

Retinal Vein Passing through a Congenital Optic Nerve Pit

open access: yesJournal of Ophthalmic & Vision Research, 2021
Hasan Kiziltoprak   +3 more
doaj   +1 more source

Illuminating the Intracellular World: Breakthroughs in Nanoscale Optoelectronics

open access: yesAdvanced Electronic Materials, EarlyView.
This perspective explores optoelectronic biointerfaces spanning macroscale flexible devices to nanoscale intracellular systems, emphasizing their integration across dimensions. It examines capacitive, Faradaic, and photothermal mechanisms that enable light‐driven control of cellular activity and highlights key material and design challenges in ...
Tania Assaf, Menahem Y. Rotenberg
wiley   +1 more source

Material Strategies for Stimulation and Recording in Neural Biocomputing Platforms

open access: yesAdvanced Electronic Materials, EarlyView.
Material strategies enabling stimulation and recording are central to neural biocomputing systems. This review examines how electronic materials govern the encoding of inputs and decoding of outputs in living neural networks. Advances in electrical, optical, and multimodal interfaces highlight emerging design principles for biocomputing platforms ...
Sehong Kang   +5 more
wiley   +1 more source

Structural features of attached retina in rhegmatogenous retinal detachments

open access: yes, 2004
Purpose: To examine the thickness and structural features of the ophthalmoscopically normal-appearing, attached retina in rhegmatogenous retinal detachments by optical coherence tomography (OCT) and compare them with those of the fellow ...
Yetik, H, Ozkan, S, Guzel, H
core   +1 more source

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

open access: yesAdvanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer   +3 more
wiley   +1 more source

Prevalence of Retinal Vascular Diseases in a Tertiary Care Hospital in Türkiye: A Hospital-Based Epidemiologic Study [PDF]

open access: yes
Objectives: To determine the prevalence of diabetic retinopathy (DR), retinal vein occlusion (RVO), and retinal artery occlusion (RAO) in a tertiary care hospital in Türkiye.
Gözde Orman   +4 more
core   +1 more source

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